Bis(7)-tacrine dihydrochloride
Based on 1 Customer Validation
Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABAAreceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease .
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 224445-12-9
- Formula: C33H42Cl2N4
- Molecular Weight:565.62
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Galanthamine
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Biological Activity
Description
Chemical Information
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CAS No. 224445-12-9
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Appearance Solid
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Molecular Weight 565.62
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Formula C33H42Cl2N4
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Color White to light yellow
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SMILES
[H]N(C1=C2C(C=CC=C2)=NC3=C1CCCC3)CCCCCCCN(C4=C5C=CC=CC5=NC6=C4CCCC6)[H].Cl.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 20 mg/mL (35.36 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Li XY, et al. Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte. Brain Res. 2010;1318:23-32. [Content Brief]
[2]. Li CY, et al. Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist. Neuroreport. 1999;10(4):795-800. [Content Brief]
[3]. Luo J, et al. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochem Biophys Res Commun. 2007;361(2):505-509. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7680 mL | 8.8399 mL | 17.6797 mL | 44.1993 mL |
| 5 mM | 0.3536 mL | 1.7680 mL | 3.5359 mL | 8.8399 mL | |
| 10 mM | 0.1768 mL | 0.8840 mL | 1.7680 mL | 4.4199 mL | |
| 15 mM | 0.1179 mL | 0.5893 mL | 1.1786 mL | 2.9466 mL | |
| 20 mM | 0.0884 mL | 0.4420 mL | 0.8840 mL | 2.2100 mL | |
| 25 mM | 0.0707 mL | 0.3536 mL | 0.7072 mL | 1.7680 mL | |
| 30 mM | 0.0589 mL | 0.2947 mL | 0.5893 mL | 1.4733 mL |
Bis(7)-tacrine dihydrochloride Related Classifications
HY-120970 Related Classifications
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