Bis(7)-tacrine dihydrochloride 

Bis(7)-tacrine dihydrochloride is a dimeric AChE inhibitor derived from tacrine. Bis(7)-tacrine dihydrochloride prevents glutamate-induced neuronal apoptosis by blocking NMDA receptors. Bis(7)-tacrine dihydrochloride is a potent GABA_Areceptor antagonist. Bis(7)-tacrine dihydrochloride has the potential for the research of Alzheimer's disease ^[1][2][3].

565.62

C₃₃H₄₂Cl₂N₄

224445-12-9

Solid

White to light yellow

[H]N(C1=C2C(C=CC=C2)=NC3=C1CCCC3)CCCCCCCN(C4=C5C=CC=CC5=NC6=C4CCCC6)[H].Cl.Cl

Room temperature in continental US; may vary elsewhere.

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Li XY, et al. Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte. Brain Res. 2010;1318:23-32.  [Content Brief]

  [2]. Li CY, et al. Bis(7)-tacrine, a novel dimeric AChE inhibitor, is a potent GABA(A) receptor antagonist. Neuroreport. 1999;10(4):795-800.  [Content Brief]

  [3]. Luo J, et al. Novel dimeric bis(7)-tacrine proton-dependently inhibits NMDA-activated currents. Biochem Biophys Res Commun. 2007;361(2):505-509.  [Content Brief]