2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Ambenonium chloride

Ambenonium chloride  (Synonyms: WIN 8077 chloride)

Cat. No.: HY-100919
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Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE).

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Ambenonium chloride Chemical Structure

Ambenonium chloride Chemical Structure

CAS No. : 115-79-7

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Based on 1 publication(s) in Google Scholar

Ambenonium chloride Related Antibodies

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Description

Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE)[1][2].

IC50 & Target

IC50: 0.7 nM (hAChE), 7 μM (hBChE)[1]
In Vitro

Ambenonium chloride inhibits Acetyicholinesterase (AChE) in a rapidly reversible method, and shows strong inhibition with inhibition constant Ki of 0.12 nM against hAChE[1].
Ambenonium chloride shows inhibitory effect towards BChE with an IC50 value of 7 μM (hBChE)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ambenonium chloride Related Antibodies
In Vivo

Ambenonium chloride (6 mg/kg; p.o.; daily; 30-60 d) results an adverse effect on neuromuscular transmission in long-term administration, and induces hypersensitivity to stimulation in myasthenia gravis mice modle[3].
Ambenonium chloride (6 mg/kg; p.o.; daily; 14 d) decreases the number of AChR in motorend-plates[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague Dawley rats (weight 250 g) with myasthenia gravis[3]
Dosage: 6 mg/kg
Administration: Oral gavage; daily; 14, 30, 60, 90, 360 days (Stop administration 24 h in advance)
Result: Resulted general activity decreasing and hypersensity to stimulation in rats during day 30-60, but these behaviors disappeared on day 90.
Induced degeneration and simplification of the postsynaptic folds, widening of the synaptic clefts, increased number of the postsynaptic vesicles, and reduction in the number of the AChR in the postsynaptic membrane on days 360.
Molecular Weight

608.47

Formula

C28H42Cl4N4O2
CAS No.
SMILES

O=C(NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)C(NCC[N+](CC)(CC)CC2=CC=CC=C2Cl)=O.[Cl-].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ambenonium chloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ambenonium115-79-7WIN 8077WIN8077WIN-8077Cholinesterase (ChE)Myasthenia Gravismotor endplateAcetyicholinesteraseneuromuscular transmissionorally activereversibleInhibitorinhibitorinhibit

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