115-79-7
115-79-7
Chemical Structure
Ambenonium chloride
Synonym(s): WIN 8077 chloride
- CAS No.: 115-79-7
- Formula:C28H42Cl4N4O2
- Molecular Weight:608.47
IUPAC Name: 2,2'-(oxalylbis(azanediyl))bis(N-(2-chlorobenzyl)-N,N-diethylethan-1-aminium) chloride
InChIKey: DXUUXWKFVDVHIK-UHFFFAOYSA-N
SMILES: O=C(NCC[N+](CC)(CC)CC1=CC=CC=C1Cl)C(NCC[N+](CC)(CC)CC2=CC=CC=C2Cl)=O.[Cl-].[Cl-]
Biological Activity: Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ambenonium chloride | 96.18% | Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE). | ||||||||||||||||||||
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Ambenonium chloride (Standard) | ≥98% | Ambenonium (chloride) (Standard) is the analytical standard of Ambenonium (chloride). This product is intended for research and analytical applications. Ambenonium (WIN 8077) chloride is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium chloride inhibits human AChE with an IC50 value of 0.7 nM (hAChE). | ||||||||||||||||||||
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Carcainium chloride (Standard) | ≥98% | Carcainium chloride (Standard) is the analytical standard of Carcainium chloride (HY-106372A). This product is intended for research and analytical applications. Carcainium chloride (QX 572) is a quaternary derivative of Lidocaine. Antitussive effect. | ||||||||||||||||||||
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AY 9944 (Standard) | 98.90% | AY 9944 (Standard) is the analytical standard of AY 9944 (HY-107420). This product is intended for research and analytical applications. AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol. | ||||||||||||||||||||
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Metalkonium chloride | Metalkonium chloride (Dodecarbonium chloride) is a quaternary ammonium salt, surfactant, and transdermal penetration enhancer. Metalkonium chloride increases skin permeability to facilitate transdermal delivery. Metalkonium chloride enhances the growth inhibitory activity of Nystatin (HY-17409) ointment against C. monosa. Metalkonium chloride can be used in studies related to Candida monosa infections. | |||||||||||||||||||||
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HBED | 98.16% | HBED is an iron-chelating antioxidant. HBED chelates ferrous iron, promotes its oxidation to ferric iron, and blocks superoxide-driven ferric iron reduction, preventing Haber-Weiss/Fenton hydroxyl radical production. HBED donates H/electrons, undergoes protonation, reduces radical cations, and forms phenoxyl radicals. HBED exerts cytoprotective effects against peroxide-induced lung fibroblast injury. HBED crosses the blood-brain barrier and mitochondrial membrane, exhibits iron affinity/selectivity, and induces iron clearance in iron-loaded monkeys. HBED reduces hippocampal AQP4, microgliosis, oxidative stress, cerebral edema, and hippocampal swelling, and improves motor function/recovery after traumatic brain injury. HBED can be used in research on iron overload and traumatic brain injury (TBI). | ||||||||||||||||||||
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Ambenonium dichloride tetrahydrate | Ambenonium (WIN 8077) dichloride tetrahydrate is an orally active and reversible inhibitor of Acetyicholinesterase (AChE) with high affinity. Ambenonium dichloride tetrahydrate inhibits human AChE with an IC50 value of 0.7 nM (hAChE). | |||||||||||||||||||||
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BCPA | 98.27% | BCPA is a Pin1 regulator without cytotoxicity. BCPA attenuates the reduction of Pin1 protein to inhibit receptor activator of RANKL-induced osteoclastogenesis. BCPA regulates osteoclast activation, used to osteoporosis research. | ||||||||||||||||||||
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cis-AY 9944 | cis-AY 9944 is a cholesterol synthesis inhibitor, exhibiting anticonvulsant activity that influences the dynamics of spike and wave discharges in EEG recordings. | |||||||||||||||||||||
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Pyramidatine | Pyramidatine (Haplamidine) is a P-glycoprotein inhibitor with an IC50 of 39.29 µM. As a sensitizer, Pyramidatine enhances Vincristine (HY-N0488A)-induced Apoptosis and G2/M phase arrest, while potentiating the activity of Vincristine against drug-resistant oral cancer. Pyramidatine can be used in research related to oral cancer and mammary adenocarcinoma. | |||||||||||||||||||||
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Denatonium benzoate | 99.87% | Denatonium benzoate (THS-839) is known as the most bitter compound and is commonly used as a deterrent (bittering agent) to activate different types of bitter taste receptors (TAS2Rs) with oral activity. Denatonium benzoate can enhance insulin secretion, has anti-inflammatory effects, and promotes allergy susceptibility . | ||||||||||||||||||||
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HBED dihydrochloride | 98.0% | HBED dihydrochloride is an iron-chelating antioxidant. HBED dihydrochloride chelates ferrous iron, promotes its oxidation to ferric iron, and blocks superoxide-driven ferric iron reduction, preventing Haber-Weiss/Fenton hydroxyl radical production. HBED dihydrochloride donates H/electrons, undergoes protonation, reduces radical cations, and forms phenoxyl radicals. HBED dihydrochloride exerts cytoprotective effects against peroxide-induced lung fibroblast injury. HBED dihydrochloride crosses the blood-brain barrier and mitochondrial membrane, exhibits iron affinity/selectivity, and induces iron clearance in iron-loaded monkeys. HBED dihydrochloride reduces hippocampal AQP4, microgliosis, oxidative stress, cerebral edema, and hippocampal swelling, and improves motor function/recovery after traumatic brain injury. HBED dihydrochloride can be used in research on iron overload and traumatic brain injury (TBI). | ||||||||||||||||||||
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References
- [1]. Hodge AS, et al. Ambenonium is a rapidly reversible noncovalent inhibitor of acetylcholinesterase, with one of the highest known affinities. Mol Pharmacol. 1992 May. 41(5):937-42. [Content Brief]
- [2]. Komloova M, et al. Preparation, in vitro screening and molecular modelling of symmetrical bis-quinolinium cholinesterase inhibitors--implications for early myasthenia gravis treatment. Bioorg Med Chem Lett. 2011 Apr 15. 21(8):2505-9. [Content Brief]
