HBED dihydrochloride

Name: HBED dihydrochloride
Brand: MedChemExpress
SKU: HY-W035520
Rating: 4.5 (1 reviews)

Cat. No.: HY-W035520 Purity: ≥95.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

HBED dihydrochloride is an orally active and hexadentate phenolic aminocarboxylate iron chelator. HBED refers to N, N'-bis(2-hydroxybenzyl)ethylenediamine-N,N'-diacetic acid, inducing iron excretion in primates. HBED dihydrochloride has the potential to be used as an alternative to desferriamine for iron chelation therapy.

For research use only. We do not sell to patients.

HBED dihydrochloride Chemical Structure

CAS No. : 35369-53-0

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 38	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 38	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Protocol
Purity & Documentation
References
Customer Review

Description

In Vivo

HBED monohydrochloride dihydrate produces different activity under different dosing methods. HBED does not produce significant effects when administered orally at doses of 81, 162, and 324 μMol/kg. After subcutaneous administration of 162 and 324 μMol/kg, the net iron excretion is increased^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

461.34

Formula

C₂₀H₂₆Cl₂N₂O₆

CAS No.

35369-53-0

Appearance

Solid

Color

White to off-white

SMILES

OC1=C(C=CC=C1)CN(CCN(CC2=C(C=CC=C2)O)CC(O)=O)CC(O)=O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (216.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.1676 mL	10.8380 mL	21.6760 mL
5 mM	0.4335 mL	2.1676 mL	4.3352 mL
10 mM	0.2168 mL	1.0838 mL	2.1676 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥95.0%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (254 KB) HNMR (130 KB)

Handling Instructions (2659 KB)

References

[1]. Bergeron RJ, et al. HBED: the continuing development of a potential alternative to deferoxamine for iron-chelating therapy. Blood. 1999 Jan 1;93(1):370-5. [Content Brief]

Animal Administration	MCE has not independently confirmed the accuracy of these methods. They are for reference only.
References	[1]. Bergeron RJ, et al. HBED: the continuing development of a potential alternative to deferoxamine for iron-chelating therapy. Blood. 1999 Jan 1;93(1):370-5. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.1676 mL	10.8380 mL	21.6760 mL	54.1900 mL
	5 mM	0.4335 mL	2.1676 mL	4.3352 mL	10.8380 mL
	10 mM	0.2168 mL	1.0838 mL	2.1676 mL	5.4190 mL
	15 mM	0.1445 mL	0.7225 mL	1.4451 mL	3.6127 mL
	20 mM	0.1084 mL	0.5419 mL	1.0838 mL	2.7095 mL
	25 mM	0.0867 mL	0.4335 mL	0.8670 mL	2.1676 mL
	30 mM	0.0723 mL	0.3613 mL	0.7225 mL	1.8063 mL
	40 mM	0.0542 mL	0.2709 mL	0.5419 mL	1.3547 mL
	50 mM	0.0434 mL	0.2168 mL	0.4335 mL	1.0838 mL
	60 mM	0.0361 mL	0.1806 mL	0.3613 mL	0.9032 mL
	80 mM	0.0271 mL	0.1355 mL	0.2709 mL	0.6774 mL
	100 mM	0.0217 mL	0.1084 mL	0.2168 mL	0.5419 mL