AY 9944 (Standard)
Based on 1 Customer Validation
AY 9944 (Standard) is the analytical standard of AY 9944 (HY-107420). This product is intended for research and analytical applications. AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme with an IC50 of 13 nM. AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.
For research use only. We do not sell to patients.
- CAS No.: 366-93-8
- Formula: C22H30Cl4N2
- Molecular Weight:464.30
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
-
HY-107420
AY 9944DHCR7 Inhibitor -
HY-17024
CyclopamineHedgehog Pathway Antagonist -
HY-10440
VismodegibHedgehog Inhibitor -
HY-13901
GANT 61Gli1/2 Inhibitor -
HY-107433
U18666ACholesterol Transport Inhibitor -
HY-15108
PurmorphamineSmoothened Receptor Agonist -
HY-13242
TaladegibSMO Antagonist -
HY-N0836
JervineAnti-cancer Agent -
HY-12316
20(S)-HydroxycholesterolSmo Activator -
HY-100224
SANT-1Smo Antagonist -
HY-13459
PF-5274857Smo Antagonist -
HY-15108G
Purmorphamine (GMP)Smo Receptor Agonist (GMP)
All Endogenous Metabolite Isoforms
More
Biological Activity
Description
IC50 & Target
IC50: 13 nM (DHCR7)1
Chemical Information
-
CAS No. 366-93-8
-
Appearance Solid
-
Molecular Weight 464.30
-
Formula C22H30Cl4N2
-
Color White to off-white
-
SMILES
ClC(C=CC=C1)=C1CNC[C@H](CC2)CC[C@@H]2CNCC3=C(C=CC=C3)Cl.[H]Cl.[H]Cl
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
-
Data Sheet (267 KB)
-
SDS (480 KB)
- English - EN (480 KB)
- Français - FR (480 KB)
- Deutsch - DE (480 KB)
- Norwegian - NO (480 KB)
- Español - ES (480 KB)
- Swedish - SV (480 KB)
- Italian - IT (480 KB)
- Korean - KR (480 KB)
- Portuguese - PT (480 KB)
-
Handling Instructions (2659 KB)
References
[1]. Moebius FF, et al. Molecular cloning and expression of the human delta7-sterol reductase. Proc Natl Acad Sci U S A. 1998 Feb 17;95(4):1899-902. [Content Brief]
[2]. Nemanic MK, et al. In vitro synthesis of vitamin D-3 by cultured human keratinocytes and fibroblasts: action spectrum and effect of AY-9944. Biochim Biophys Acta. 1985 Sep 6;841(3):267-77. [Content Brief]
[3]. Cortez MA, et al. Brain sterols in the AY-9944 rat model of atypical absence seizures. Epilepsia. 2002 Jan;43(1):3-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AY 9944 (Standard) Related Classifications
HY-107420R Related Classifications
Powered by Bioz