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AY 9944 

Cat. No.: HY-107420 Purity: >99.0%
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AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol.

For research use only. We do not sell to patients.

AY 9944 Chemical Structure

AY 9944 Chemical Structure

CAS No. : 366-93-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 695 In-stock
Estimated Time of Arrival: December 31
1 mg USD 320 In-stock
Estimated Time of Arrival: December 31
5 mg USD 680 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

AY 9944 is a specific cholesterol biosynthesis inhibitor. AY 9944 inhibits the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM). AY 9944 causes hypocholesterolemia and accumulation of 7DHC. At high doses, AY 9944 inhibits also in cultured embryos sterol Δ7-Δ8 isomerase, which causes the accumulation of cholest-8-en-3β-ol[1][2][3].

Molecular Weight

464.30

Formula

C₂₂H₃₀Cl₄N₂

CAS No.

366-93-8

SMILES

ClC(C=CC=C1)=C1CNC[[email protected]](CC2)CC[[email protected]@H]2CNCC3=C(C=CC=C3)Cl.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >99.0%

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Keywords:

AY 9944AY9944AY-9944Otherscholesterolreductasebiosynthesis7DHCaccumulationΔ7-Δ8isomerasehypocholesterolemiaInhibitorinhibitorinhibit

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Product name:
AY 9944
Cat. No.:
HY-107420
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