2. Stem Cell/Wnt
  3. Smo
  4. Purmorphamine

Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM.

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Purmorphamine

Purmorphamine Chemical Structure

CAS No. : 483367-10-8

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Based on 1 publication(s) in Google Scholar

Purmorphamine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Purmorphamine

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  • Purity & Documentation

  • References

  • Customer Review

Description

Purmorphamine (GMP) is Purmorphamine (HY-15108) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. Purmorphamine is a smoothened/Smo receptor agonist with an EC50 of 1 μM[1].

Cellular Effect
Cell Line Type Value Description References
C3H 10T1/2 EC50
0.8 μM
Compound: Purmorph
Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay
Activity at Smo in mouse C3H10T1/2 cells assessed as induction of cell differentiation into osteoblast incubated for 6 days by alkaline phosphatase assay
[PMID: 27429255]
C3H 10T1/2 EC50
1 μM
Compound: Purmorphamine
Induction of osteogenesis in mouse C3H10T1/2 cells assessed as induction of osteoblast specific marker alkaline phosphatase by immunofluorescence method
Induction of osteogenesis in mouse C3H10T1/2 cells assessed as induction of osteoblast specific marker alkaline phosphatase by immunofluorescence method
[PMID: 16408003]
HEK-293T IC50
1.5 μM
Compound: 3
Inhibition of BODIPY-cyclopamine binding to Smo expressed in HEK293T cells after 1 hr by fluorescence microscopy
Inhibition of BODIPY-cyclopamine binding to Smo expressed in HEK293T cells after 1 hr by fluorescence microscopy
[PMID: 16408088]
Shh Light II EC50
1 μM
Compound: 3
Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assay
Activation of Shh in mouse Shh Light2 cells after 30 hrs by luciferase reporter gene assay
[PMID: 16408088]
In Vitro

Purmorphamine (GMP) (1.5 μM, 1 week) can generate embryoid bodies (EBs) from human iPS cells (hiPS2) and hESCs (HSF1)[1].
Purmorphamine (GMP) (1.5 μM) converts hPSCs to NKX2-1 positive MGE cells[2].
Purmorphamine (GMP) (2 μM, day 28-35) promotes ventralization of the brain spheroids in differentiation process from hiPSCs[3].
Purmorphamine (GMP) (1 μM) together with retinoic acid (RA, 2 μM) promotes hiPSC differentiation into functional neural tissue, indicated by the expression of neuronal marker β-tubulin III (βT-III)[4].
Purmorphamine (GMP) (day5-7) induces hESCs differentiation into dopaminergic (DA) neurons[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Purmorphamine Related Antibodies
Molecular Weight

520.62

Formula

C31H32N6O2
CAS No.
Appearance

Solid

Color

Off-white to pale purple

SMILES

N1(C2=CC=C(NC3=NC(OC4=CC=CC5=C4C=CC=C5)=NC6=C3N=CN6C7CCCCC7)C=C2)CCOCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Purmorphamine Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Purmorphamine (GMP)483367-10-8SmoSmoothenedGMPcell therapydifferentiatecardiachiPSCsstem cellhESCneuronInhibitorinhibitorinhibit

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