1. Stem Cell/Wnt
  2. Smo

LY2940680 (Synonyms: Taladegib)

Cat. No.: HY-13242 Purity: 99.76%
Handling Instructions

LY2940680 is an antagonist of the smoothened receptor.

For research use only. We do not sell to patients.
LY2940680 Chemical Structure

LY2940680 Chemical Structure

CAS No. : 1258861-20-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 149 In-stock
5 mg USD 132 In-stock
10 mg USD 192 In-stock
50 mg USD 540 In-stock
100 mg USD 1020 In-stock
200 mg   Get quote  
500 mg   Get quote  

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

LY2940680 is an antagonist of the smoothened receptor.

IC50 & Target

Smo[1]

In Vitro

LY2940680, a small-molecule antagonist of the smoothened receptor, shows a slight inhibitory effect on cell proliferation without differences between mucin- (IC50: LY2940680=49.8±4.5 μM) and mixed- Cholangiocarcinoma (CCA) (IC50: LY2940680=61.2±21.1 μM)[1]. The IC50 for LY2940680 inhibition of [3H]MRT-92 binding is right shifted (3- to 100-fold) for the S387AECL2, L325F3.36f, and D473H6.54f mutants but did not differ from that of WT receptor for the other mutants. The ability of SANT-1 to inhibit [3H]MRT-92 binding to V329F3.40f and T466F6.47f mutants is abolished, and it is severely impaired for L325F3.40f, I408F5.51f, and M525G7.45f mutants (4- to 140-fold drop of the IC50), but is not modified for the S387AECL2 mutant. Taken together, these data confirm our docking hypothesis that MRT-92-binding mode differs from that of either LY2940680 or SANT-1 by simultaneously occupying binding sites 1 and 2[2].

Clinical Trial
References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 1.9512 mL 9.7561 mL 19.5122 mL
5 mM 0.3902 mL 1.9512 mL 3.9024 mL
10 mM 0.1951 mL 0.9756 mL 1.9512 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

512.5

Formula

C₂₆H₂₄F₄N₆O

CAS No.

1258861-20-9

SMILES

CN1N=CC=C1C2=C3C(C=CC=C3)=C(N=N2)N4CCC(CC4)N(C)C(C5=C(C=C(C=C5)F)C(F)(F)F)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 5.2 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
LY2940680
Cat. No.:
HY-13242
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