2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Acephate

Acephate 

Cat. No.: HY-B0841 Purity: ≥98.0%
COA Handling Instructions

Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture.

For research use only. We do not sell to patients.

Acephate Chemical Structure

Acephate Chemical Structure

CAS No. : 30560-19-1

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Based on 1 publication(s) in Google Scholar

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Description

Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture[1].

IC50 & Target

AChE

 

In Vitro

In rat immature Leydig cells after 3-h culture, Acephate inhibits basal androgen output in a dose-dependent manner with the inhibition starting at 0.5 μM. Acephate significantly inhibits luteinizing hormone and 8-Br-cAMP stimulated androgen output at 50 μM. Acephate significantly inhibits progesterone-mediated androgen output at 50 μM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo

Adult male mice are gavaged with 0, 7, 14, and 28 mg/kg/day acephate for 28 d and sperm motility and number are decreased at 14 and 28 mg/kg/day[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

183.17

Appearance

Solid

Formula

C4H10NO3PS
CAS No.
SMILES

O=P(SC)(NC(C)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (682.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4594 mL 27.2970 mL 54.5941 mL
5 mM 1.0919 mL 5.4594 mL 10.9188 mL
10 mM 0.5459 mL 2.7297 mL 5.4594 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (545.94 mM); Clear solution; Need ultrasonic

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (243 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Acephate30560-19-1Cholinesterase (ChE)anticholinesterase insecticideAChE insectsInhibitorinhibitorinhibit

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