2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Acephate

Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture.

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Acephate Chemical Structure

Acephate Chemical Structure

CAS No. : 30560-19-1

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100 mg USD 80 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Acephate:

Acephate Related Antibodies

Top Publications Citing Use of Products

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Acephate is a broad-spectrum anticholinesterase insecticide. Acephate acts via inhibiting AChE (Cholinesterase (ChE)) activity of insects. Acephate is used for control of several species of insects in agriculture and in horticulture[1].

IC50 & Target

AChE

 

In Vitro

In rat immature Leydig cells after 3-h culture, Acephate inhibits basal androgen output in a dose-dependent manner with the inhibition starting at 0.5 μM. Acephate significantly inhibits luteinizing hormone and 8-Br-cAMP stimulated androgen output at 50 μM. Acephate significantly inhibits progesterone-mediated androgen output at 50 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Acephate Related Antibodies
In Vivo

Adult male mice are gavaged with 0, 7, 14, and 28 mg/kg/day acephate for 28 d and sperm motility and number are decreased at 14 and 28 mg/kg/day[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

183.17

Formula

C4H10NO3PS
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=P(SC)(NC(C)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (682.43 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.4594 mL 27.2970 mL 54.5941 mL
5 mM 1.0919 mL 5.4594 mL 10.9188 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (545.94 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (249 KB) HNMR (243 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.4594 mL 27.2970 mL 54.5941 mL 136.4852 mL
5 mM 1.0919 mL 5.4594 mL 10.9188 mL 27.2970 mL
10 mM 0.5459 mL 2.7297 mL 5.4594 mL 13.6485 mL
15 mM 0.3640 mL 1.8198 mL 3.6396 mL 9.0990 mL
20 mM 0.2730 mL 1.3649 mL 2.7297 mL 6.8243 mL
25 mM 0.2184 mL 1.0919 mL 2.1838 mL 5.4594 mL
30 mM 0.1820 mL 0.9099 mL 1.8198 mL 4.5495 mL
40 mM 0.1365 mL 0.6824 mL 1.3649 mL 3.4121 mL
50 mM 0.1092 mL 0.5459 mL 1.0919 mL 2.7297 mL
60 mM 0.0910 mL 0.4550 mL 0.9099 mL 2.2748 mL
80 mM 0.0682 mL 0.3412 mL 0.6824 mL 1.7061 mL
100 mM 0.0546 mL 0.2730 mL 0.5459 mL 1.3649 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Acephate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Acephate30560-19-1Cholinesterase (ChE)anticholinesterase insecticideAChE insectsInhibitorinhibitorinhibit

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