ACG548B
Based on 1 Customer Validation
ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase). ACG548B can be uesd for the study of myasthenia gravis and neuromuscular blockade.
For research use only. We do not sell to patients.
- Purity: 99.72%
- CAS No.: 795316-16-4
- Formula: C38H34Br2Cl2N4
- Molecular Weight:777.42
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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AChE 1.78 μM (IC50) |
BChE 0.496 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HT-29 | IC50 |
1.9 μM
Compound: 19
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Antiproliferative activity was determined using HT-29 human colon cancer cell line
Antiproliferative activity was determined using HT-29 human colon cancer cell line
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[PMID: 15481981] |
Chemical Information
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CAS No. 795316-16-4
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Appearance Solid
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Molecular Weight 777.42
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Formula C38H34Br2Cl2N4
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Color Yellow to brown
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SMILES
CN(C1=CC=[N+](CC2=CC(C3=CC=CC(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C=C4)=C3)=CC=C2)C=C1)C6=CC=C(Cl)C=C6.[Br-].[Br-]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (64.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.2863 mL | 6.4315 mL | 12.8631 mL | 32.1577 mL |
| 5 mM | 0.2573 mL | 1.2863 mL | 2.5726 mL | 6.4315 mL | |
| 10 mM | 0.1286 mL | 0.6432 mL | 1.2863 mL | 3.2158 mL | |
| 15 mM | 0.0858 mL | 0.4288 mL | 0.8575 mL | 2.1438 mL | |
| 20 mM | 0.0643 mL | 0.3216 mL | 0.6432 mL | 1.6079 mL | |
| 25 mM | 0.0515 mL | 0.2573 mL | 0.5145 mL | 1.2863 mL | |
| 30 mM | 0.0429 mL | 0.2144 mL | 0.4288 mL | 1.0719 mL | |
| 40 mM | 0.0322 mL | 0.1608 mL | 0.3216 mL | 0.8039 mL | |
| 50 mM | 0.0257 mL | 0.1286 mL | 0.2573 mL | 0.6432 mL | |
| 60 mM | 0.0214 mL | 0.1072 mL | 0.2144 mL | 0.5360 mL |
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