Uridine 5'-monophosphate-¹⁵N₂,d₁₁ dilithium  (Synonyms: 5'-​Uridylic acid-15N2,d11 dilithium)

Uridine 5'-monophosphate-¹⁵N₂,d₁₁ (5'- Uridylic acid-¹⁵N₂,d₁₁) dilithium is deuterium and ¹⁵N labeled Uridine 5'-monophosphate (HY-101981). Uridine 5'-monophosphate (5'-Uridylic acid) is an orally active mitochondrial ATP-dependent potassium channel activator that has a protective effect on the heart. Uridine 5'-monophosphate can promote the synthesis of CDP-choline and induce apoptosis in intestinal epithelial cells, which is beneficial for gut development and reduces diarrhea^[1][2][3].

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

349.10

C₉D₁₁Li₂¹⁵N₂O₉P

58-97-9

O=P(O[Li])(O[Li])OC([2H])([2H])[C@@]1([2H])O[C@]([15N](C([15N]2[2H])=O)C([2H])=C([2H])C2=O)([2H])[C@](O[2H])([2H])[C@]1([2H])O[2H]

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Li G, et al. Uridine/UMP metabolism and their function on the gut in segregated early weaned piglets. Food Funct. 2019 Jul 17;10(7):4081-4089.  [Content Brief]

  [2]. Mehmet Cansev, et al. Oral uridine-5'-monophosphate (UMP) increases brain CDP-choline levels in gerbils. Brain Res. 2005 Oct 5;1058(1-2):101-8.  [Content Brief]

  [3]. Irina B Krylova, et al. The cardioprotective effect of uridine and uridine-5'-monophosphate: the role of the mitochondrial ATP-dependent potassium channel. Exp Gerontol. 2006 Jul;41(7):697-703.  [Content Brief]