Hepcidin/HAMP Protein, Human (GST)
Based on 1 publication(s) in Google Scholar
The hepcidin/HAMP protein is a liver-produced hormone that is a major circulating regulator of iron absorption and distribution. It promotes endocytosis and degradation of ferroportin/SLC40A1, retaining iron within cells and reducing plasma iron flux. Hepcidin/HAMP Protein, Human (GST) is the recombinant human-derived Hepcidin/HAMP protein, expressed by E. coli , with N-GST labeled tag.
- Species: Human
- Source: E. coli
-
Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Technical Parameters
-
Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
The hepcidin/HAMP protein is a liver-produced hormone that is a major circulating regulator of iron absorption and distribution. It promotes endocytosis and degradation of ferroportin/SLC40A1, retaining iron within cells and reducing plasma iron flux. Hepcidin/HAMP Protein, Human (GST) is the recombinant human-derived Hepcidin/HAMP protein, expressed by E. coli , with N-GST labeled tag.
Background
Hepcidin, a liver-produced hormone, serves as the principal circulating regulator of iron absorption and distribution throughout the body. Its regulatory mechanism involves promoting the endocytosis and degradation of ferroportin/SLC40A1, resulting in the retention of iron within iron-exporting cells and a reduction in the flow of iron into the plasma. Hepcidin governs crucial iron fluxes into the bloodstream, including the absorption of dietary iron in the intestine, the recycling of iron by macrophages through phagocytosis of aging erythrocytes and other cells, and the mobilization of stored iron from hepatocytes. Additionally, hepcidin exhibits robust antimicrobial activity against various bacteria, including E.coli ML35P, N.cinerea, S.epidermidis, S.aureus, and group B streptococcus, as well as moderate activity against the fungus C.albicans, while showing no efficacy against P.aeruginosa.
MCE Validation Data
-
Purity - SDS-PAGE
Purity - SDS-PAGE
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Cell Stem Cell
Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems. [Abstract]2026 May 15:S1934-5909(26)00158-X. PMID: 42143017
Technical Parameters
-
Species Human
-
Source E. coli
-
Tag N-GST
-
Accession
P81172 (D60-T84)
-
Molecular Construction
-
N-term
-
GST
-
Hepcidin (D60-T84)
Accession # P81172 -
C-term
-
-
Protein Length
Full Length of Hepcidin-25 Peptide
-
Synonyms
HAMP; Liver-Expressed Antimicrobial Peptide 1; Hepcidin Antimicrobial Peptide; Putative Liver Tumor Regressor; LEAP1; Hepcidin; HEPC; PLTR; LEAP-1; Hepcidin Preproprotein; HFE2B
-
AA Sequence
DTHFPICIFCCGCCHRSKCGMCCKT
-
Predicted Molecular Mass
29.2 kDa
-
Molecular Weight
Approximately 28-30 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
-
Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution
Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.
<1 EU/μg, determined by LAL method.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
-
Data Sheet (234 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz
