Hepcidin/HAMP Protein, Human (GST)

The hepcidin/HAMP protein is a liver-produced hormone that is a major circulating regulator of iron absorption and distribution. It promotes endocytosis and degradation of ferroportin/SLC40A1, retaining iron within cells and reducing plasma iron flux. Hepcidin/HAMP Protein, Human (GST) is the recombinant human-derived Hepcidin/HAMP protein, expressed by E. coli , with N-GST labeled tag.

Hepcidin, a liver-produced hormone, serves as the principal circulating regulator of iron absorption and distribution throughout the body. Its regulatory mechanism involves promoting the endocytosis and degradation of ferroportin/SLC40A1, resulting in the retention of iron within iron-exporting cells and a reduction in the flow of iron into the plasma. Hepcidin governs crucial iron fluxes into the bloodstream, including the absorption of dietary iron in the intestine, the recycling of iron by macrophages through phagocytosis of aging erythrocytes and other cells, and the mobilization of stored iron from hepatocytes. Additionally, hepcidin exhibits robust antimicrobial activity against various bacteria, including E.coli ML35P, N.cinerea, S.epidermidis, S.aureus, and group B streptococcus, as well as moderate activity against the fungus C.albicans, while showing no efficacy against P.aeruginosa.

Human

E. coli

N-GST

P81172 (D60-T84)

57817  [NCBI]

Full Length of Hepcidin-25

DTHFPICIFCCGCCHRSKCGMCCKT

28-30 kDa

≥ 90%, as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.