Hepcidin/HAMP Protein, Human (GST)

The hepcidin/HAMP protein is a liver-produced hormone that is a major circulating regulator of iron absorption and distribution. It promotes endocytosis and degradation of ferroportin/SLC40A1, retaining iron within cells and reducing plasma iron flux. Hepcidin/HAMP Protein, Human (GST) is the recombinant human-derived Hepcidin/HAMP protein, expressed by E. coli , with N-GST labeled tag. The total length of Hepcidin/HAMP Protein, Human (GST) is 25 a.a., with molecular weight of 28-30 kDa.

Hepcidin, a liver-produced hormone, serves as the principal circulating regulator of iron absorption and distribution throughout the body. Its regulatory mechanism involves promoting the endocytosis and degradation of ferroportin/SLC40A1, resulting in the retention of iron within iron-exporting cells and a reduction in the flow of iron into the plasma. Hepcidin governs crucial iron fluxes into the bloodstream, including the absorption of dietary iron in the intestine, the recycling of iron by macrophages through phagocytosis of aging erythrocytes and other cells, and the mobilization of stored iron from hepatocytes. Additionally, hepcidin exhibits robust antimicrobial activity against various bacteria, including E.coli ML35P, N.cinerea, S.epidermidis, S.aureus, and group B streptococcus, as well as moderate activity against the fungus C.albicans, while showing no efficacy against P.aeruginosa.

Human

E. coli

N-GST

P81172 (D60-T84)

57817  [NCBI]

DTHFPICIFCCGCCHRSKCGMCCKT

28-30 kDa

Greater than 90% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, 50% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.