2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Hepcidin
  5. Hepcidin Activator

Hepcidin Activator

Hepcidin Activator (1):

Cat. No. Product Name Effect Purity
  • HY-P992451
    RLYB331
    		Activator
    RLYB331 (KY1066) is a is a monoclonal antibody targeting Matriptase-2 (TMPRSS6). RLYB331 binds to the serine protease active site of matriptase-2, blocking protease activity to increase hepcidin expression. RLYB331 reduces iron overload, inhibits α-aggregates, reduces ROS, inhibits apoptosis, and enhances erythroid differentiation. RLYB331 ameliorates ineffective erythropoiesis in β-thalassemic mouse models. RLYB331 can be used for the research of β-thalassemia.