2. Metabolic Enzyme/Protease Anti-infection
  3. Hepcidin Bacterial
  4. Hepcidin-25 (human) TFA

Hepcidin-25 (human) TFA is an iron metabolism modulator and Antimicrobial agent. Hepcidin-25 (human) TFA shows anti-inflammatory and anti-bacterial activity via modulation of iron-mediated oxidant injury.

For research use only. We do not sell to patients.

Hepcidin-25 (human) TFA

Hepcidin-25 (human) TFA Chemical Structure

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500 μg In-stock
1 mg In-stock
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Other Forms of Hepcidin-25 (human) TFA:

Hepcidin-25 (human) TFA Related Antibodies

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Description

Hepcidin-25 (human) TFA is an iron metabolism modulator and Antimicrobial agent. Hepcidin-25 (human) TFA shows anti-inflammatory and anti-bacterial activity via modulation of iron-mediated oxidant injury[1].

Parmacokinetics
Species Dose Route T1/2 (Elimination)
Macaques 11.1 nM i.v. 1.2 mg/mL
Molecular Weight

2789.35 (free base)

Formula

C113H170N34O31S9.xC2HF3O2
Appearance

Solid

Sequence

Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr (Disulfide bridge:Cys7-Cys23; Cys10-Cys13; Cys11-Cys19; Cys14-Cys22)
Sequence Shortening

DTHFPICIFCCGCCHRSKCGMCCKT (Disulfide bridge:Cys7-Cys23; Cys10-Cys13; Cys11-Cys19; Cys14-Cys22)
SMILES

OC(C[C@H](N)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC1=CN=CN1)C(N[C@@H](CC2=CC=CC=C2)C(N3[C@@H](CCC3)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]4C(N[C@@](C(N[C@H](C(N[C@]5([H])C(N[C@@]6([H])CSSC[C@@]7([H])C(NCC(N[C@H](C(N[C@](CSSC[C@@](NC([C@](NC(CNC6=O)=O)([H])CSSC5)=O)([H])C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N7)=O)CCCCN)=O)CO)=O)CCCNC(N)=N)=O)CC8=CN=CN8)=O)([H])C(N[C@@H](CSSC4)C(N[C@@H](CCCCN)C(N[C@H](C(O)=O)[C@H](O)C)=O)=O)=O)=O)CCSC)=O)=O)=O)=O)CC9=CC=CC=C9)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O.O=C(O)C(F)(F)F.[x]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 25 mg/mL

*"≥" means soluble, but saturation unknown.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References
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Hepcidin-25 (human) TFA Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Hepcidin-25 (human)HepcidinBacterialanti-inflammatory activityanti-bacterial activityiron-mediated oxidant injuryInhibitorinhibitorinhibit

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