TYRO3/DTK Protein, Mouse (HEK293, hFc)

The TYRO3/DTK protein, a receptor tyrosine kinase, transduces signals from the extracellular matrix by binding to various ligands, including TULP1 or GAS6. It plays a crucial role in regulating numerous physiological processes, encompassing cell survival, migration, and differentiation. Upon ligand binding at the cell surface, TYRO3 undergoes dimerization and autophosphorylation on its intracellular domain, creating docking sites for downstream signaling molecules. Upon activation, TYRO3 interacts with PIK3R1, enhancing PI3-kinase activity and activating the AKT survival pathway, leading to nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling is implicated in processes such as neuron protection from excitotoxic injury, platelet aggregation, and cytoskeleton reorganization. Additionally, TYRO3 plays a crucial role in inhibiting Toll-like receptors (TLRs)-mediated innate immune responses by activating STAT1, which selectively induces the production of suppressors of cytokine signaling SOCS1 and SOCS3.