Tyro3 - TYRO3 protein tyrosine kinase 3 Gene

Also Known as Brt; Dtk; Rse; Sky; Tif; Etk-2; TK19-2; tk19-1; etk2/tyro3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 22174

Summary

Predicted to enable phosphatidylinositol 3-kinase binding activity; transmembrane receptor protein tyrosine kinase activity; and virus receptor activity. Involved in several processes, including negative regulation of defense response; platelet aggregation; and protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; platelet activation; and substrate adhesion-dependent cell spreading. Predicted to be located in cell surface; endoplasmic reticulum membrane; and nuclear envelope. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; limb; and sensory organ. Orthologous to human Tyro3 (Tyro3 protein tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Tyro3 Products (2)

mRNA Protein Name
NM_001290800.1 NP_001277729.1 tyrosine-protein kinase receptor TYRO3 isoform B
NM_019392.2 NP_062265.2 tyrosine-protein kinase receptor TYRO3 isoform A precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18787040 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
17442946 MGI
involved in apoptotic cell clearance IGI
IGI: Inferred from genetic interaction
18159085 MGI
acts upstream of or within establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within forebrain cell migration IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of or within natural killer cell differentiation IGI
IGI: Inferred from genetic interaction
16751775 MGI
involved in negative regulation of inflammatory response IGI
IGI: Inferred from genetic interaction
18083102 MGI
involved in negative regulation of innate immune response IGI
IGI: Inferred from genetic interaction
18083102 MGI
acts upstream of or within negative regulation of lymphocyte activation IGI
IGI: Inferred from genetic interaction
11452127 MGI
acts upstream of or within negative regulation of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
18787040 MGI
involved in negative regulation of toll-like receptor signaling pathway IGI
IGI: Inferred from genetic interaction
18083102 MGI
acts upstream of neuron apoptotic process IGI
IGI: Inferred from genetic interaction
18787040 MGI
involved in neuron cellular homeostasis IMP
IMP: Inferred from mutant phenotype
21084607 MGI
acts upstream of or within neuron migration IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within neuropeptide signaling pathway IMP
IMP: Inferred from mutant phenotype
9331176 MGI
acts upstream of or within ovulation cycle IGI
IGI: Inferred from genetic interaction
18787040 MGI
acts upstream of or within platelet activation IMP
IMP: Inferred from mutant phenotype
15650770 MGI
involved in platelet aggregation IMP
IMP: Inferred from mutant phenotype
20546121 MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
IGI: Inferred from genetic interaction
15650770 MGI
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
21084607 MGI
acts upstream of or within secretion by cell IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within spermatogenesis IGI
IGI: Inferred from genetic interaction
10227296 MGI
involved in spermatogenesis IGI
IGI: Inferred from genetic interaction
10227296 MGI
acts upstream of or within substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
15650770 MGI
acts upstream of or within vagina development IGI
IGI: Inferred from genetic interaction
18393392 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tyrosine-protein kinase receptor TYRO3

  • receptor tyrosine kinase

  • tyrosine-protein kinase DTK

  • tyrosine-protein kinase RSE

  • tyrosine-protein kinase TIF

Recombinant Tyro3 Proteins

Cat. No. Product Name Accession Purity
HY-P70043 TYRO3/DTK Protein, Mouse (HEK293, hFc) P55144 (A31-S418) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77863 TYRO3/DTK Protein, Mouse (HEK293, His) P55144-2 (R31-D419) ≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-12076 BMS 777607 Inhibitor 99.36% Phase 2
HY-114358 Tamnorzatinib Inhibitor 98.59% Phase 2
HY-147218 PF-07265807 Inhibitor 95.18% Phase 1

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12494 LDC1267 Inhibitor 99.64% Unkown
HY-117596 UNC569 Inhibitor 99.92% Unkown
HY-132200 UNC5293 Inhibitor 99.93% Unkown
HY-173268 UNC9426 Inhibitor 99.51% Unkown
HY-117548 UNC1062 Inhibitor 98.92% Unkown
HY-124502 UNC4203 Inhibitor 99.80% Unkown
HY-162085 Axl-IN-17 Inhibitor / Unkown
HY-173400 UNC8212 Inhibitor / Unkown
HY-115778 UNC3133 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tyro3 NCBI NCBI:7301