PF-07265807
Based on 1 Customer Validation
PF-07265807 (ARRY-067) is a kinase inhibitor with primary targets AXL, MERTK, and TYRO3. PF-07265807 acts as an immunomodulator that cross-activates CD8+ T cells by enhancing dendritic cell function. PF-07265807 blocks downstream signal transduction of AXL and MERTK, and inhibits the proliferation and migration of tumor cells with high expression of these two kinases. PF-07265807 is applicable to research related to advanced or metastatic solid tumors, such as colorectal cancer.
For research use only. We do not sell to patients.
- Purity: 95.18%
- CAS No.: 2412356-57-9
- Formula: C29H27F2N7O5
- Molecular Weight:591.57
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Kinase Inhibitor Library
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Posttranslational Modification Library
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Biological Activity
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Axl 0.9 nM (IC50) |
Tyro3 6 nM (IC50) |
Mer 2.3 nM (IC50) |
PF-07265807, an AXL/MER inhibitor, enhances dendritic cell cross-priming of CD8+ T cells in preclinical in vitro immune cell assays[1].
PF-07265807 (example 72) potently inhibits purified AXL, MER, and TYRO3 TAM kinases with IC50 values of 0.9 nM, 2.3 nM, and 6 nM, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 2412356-57-9
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Appearance Solid
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Molecular Weight 591.57
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Formula C29H27F2N7O5
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Color Light yellow to yellow
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SMILES
OC[C@@H](C)NC1=NNC2=NC=CC(OC3=C(C=C(C=C3)NC(C(C(N4C5=CC=C(C=C5)F)=O)=CN(C(C)C)C4=O)=O)F)=C12
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Synonyms
ARRY-067
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 200 mg/mL (338.08 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Portuguese - PT (254 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6904 mL | 8.4521 mL | 16.9042 mL | 42.2604 mL |
| 5 mM | 0.3381 mL | 1.6904 mL | 3.3808 mL | 8.4521 mL | |
| 10 mM | 0.1690 mL | 0.8452 mL | 1.6904 mL | 4.2260 mL | |
| 15 mM | 0.1127 mL | 0.5635 mL | 1.1269 mL | 2.8174 mL | |
| 20 mM | 0.0845 mL | 0.4226 mL | 0.8452 mL | 2.1130 mL | |
| 25 mM | 0.0676 mL | 0.3381 mL | 0.6762 mL | 1.6904 mL | |
| 30 mM | 0.0563 mL | 0.2817 mL | 0.5635 mL | 1.4087 mL | |
| 40 mM | 0.0423 mL | 0.2113 mL | 0.4226 mL | 1.0565 mL | |
| 50 mM | 0.0338 mL | 0.1690 mL | 0.3381 mL | 0.8452 mL | |
| 60 mM | 0.0282 mL | 0.1409 mL | 0.2817 mL | 0.7043 mL | |
| 80 mM | 0.0211 mL | 0.1057 mL | 0.2113 mL | 0.5283 mL | |
| 100 mM | 0.0169 mL | 0.0845 mL | 0.1690 mL | 0.4226 mL |
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