1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR
  3. Bozitinib

Bozitinib (Synonyms: PLB-1001; CBT-101)

Cat. No.: HY-125017
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Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily.

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Bozitinib Chemical Structure

Bozitinib Chemical Structure

CAS No. : 1440964-89-5

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Description

Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily[1].

In Vitro

Bozitinib (PLB-1001) (30 μM; 6 hours) inhibits the phosphorylation of MET and STAT3, has a robust inhibitory effect of PLB-1001 on MET and its downstream signaling pathways.

Western Blot Analysis[1]

Cell Line: Human astrocytes (HA) cells
Concentration: 30 μM
Incubation Time: 6 hours
Result: Decreased p-STAT3,p-MET expression.
Molecular Weight

424.38

Formula

C₂₀H₁₅F₃N₈

CAS No.

1440964-89-5

SMILES

CN1N=C2C=C(F)C(C(C3=NN=C4C=CC(C5=CN(C6CC6)N=C5)=NN43)(F)F)=CC2=C1

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