1440964-89-5
Chemical Structure
Bozitinib
Synonym(s): PLB-1001; CBT-101; Vebreltinib
- CAS No.: 1440964-89-5
- Formula:C20H15F3N8
- Molecular Weight:424.38
IUPAC Name: 6-(1-cyclopropyl-1H-pyrazol-4-yl)-3-(difluoro(6-fluoro-2-methyl-2H-indazol-5-yl)methyl)-[1,2,4]triazolo[4,3-b]pyridazine
InChIKey: QHXLXUIZUCJRKV-UHFFFAOYSA-N
SMILES: CN1N=C2C=C(F)C(C(C3=NN=C4C=CC(C5=CN(C6CC6)N=C5)=NN43)(F)F)=CC2=C1
Biological Activity: Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily[1].
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Bozitinib | 98.88% | Bozitinib (PLB-1001) is a highly selective c-MET kinase inhibitor with blood-brain barrier permeability. Bozitinib (PLB-1001) is a ATP-competitive small-molecule inhibitor, binds to the conventional ATP-binding pocket of the tyrosine kinase superfamily. | ||||||||||||||||||||
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Keywords
