2412356-57-9

PF-07265807 Chemical Structure
2412356-57-9

Chemical Structure

PF-07265807

Synonym(s): ARRY-067

  • CAS No.: 2412356-57-9
  • Formula:C29H27F2N7O5
  • Molecular Weight:591.57

IUPAC Name: 4-((2-(4-(1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

InChIKey: ILVXQVHFMCJXTE-MRXNPFEDSA-N

SMILES: OC[C@@H](C)NC1=NNC2=NC=CC(OC3=C(C=C(C=C3)NC(C(C(N4C5=CC=C(C=C5)F)=O)=CN(C(C)C)C4=O)=O)F)=C12

Biological Activity: PF-07265807 (ARRY-067) is a kinase inhibitor with primary targets AXL, MERTK, and TYRO3. PF-07265807 acts as an immunomodulator that cross-activates CD8+ T cells by enhancing dendritic cell function. PF-07265807 blocks downstream signal transduction of AXL and MERTK, and inhibits the proliferation and migration of tumor cells with high expression of these two kinases. PF-07265807 is applicable to research related to advanced or metastatic solid tumors, such as colorectal cancer[1][2][3].

Cat. No. Product Name Purity Description Pricing
HY-147218 		PF-07265807 95.18% PF-07265807 (ARRY-067) is a kinase inhibitor with primary targets AXL, MERTK, and TYRO3. PF-07265807 acts as an immunomodulator that cross-activates CD8+ T cells by enhancing dendritic cell function. PF-07265807 blocks downstream signal transduction of AXL and MERTK, and inhibits the proliferation and migration of tumor cells with high expression of these two kinases. PF-07265807 is applicable to research related to advanced or metastatic solid tumors, such as colorectal cancer.
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