2412356-57-9
Chemical Structure
PF-07265807
Synonym(s): ARRY-067
- CAS No.: 2412356-57-9
- Formula:C29H27F2N7O5
- Molecular Weight:591.57
IUPAC Name: 4-((2-(4-(1-(4-((5-chloro-4-((2-(dimethylphosphoryl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)piperidin-4-yl)piperazin-1-yl)-2-oxoethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
InChIKey: ILVXQVHFMCJXTE-MRXNPFEDSA-N
SMILES: OC[C@@H](C)NC1=NNC2=NC=CC(OC3=C(C=C(C=C3)NC(C(C(N4C5=CC=C(C=C5)F)=O)=CN(C(C)C)C4=O)=O)F)=C12
Biological Activity: PF-07265807 (ARRY-067) is a kinase inhibitor with primary targets AXL, MERTK, and TYRO3. PF-07265807 acts as an immunomodulator that cross-activates CD8+ T cells by enhancing dendritic cell function. PF-07265807 blocks downstream signal transduction of AXL and MERTK, and inhibits the proliferation and migration of tumor cells with high expression of these two kinases. PF-07265807 is applicable to research related to advanced or metastatic solid tumors, such as colorectal cancer[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PF-07265807 | 95.18% | PF-07265807 (ARRY-067) is a kinase inhibitor with primary targets AXL, MERTK, and TYRO3. PF-07265807 acts as an immunomodulator that cross-activates CD8+ T cells by enhancing dendritic cell function. PF-07265807 blocks downstream signal transduction of AXL and MERTK, and inhibits the proliferation and migration of tumor cells with high expression of these two kinases. PF-07265807 is applicable to research related to advanced or metastatic solid tumors, such as colorectal cancer. | ||||||||||||||||||||
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References
- [1]. Sang YB, et al. The Development of AXL Inhibitors in Lung Cancer: Recent Progress and Challenges. Front Oncol. 2022;12:811247. Published 2022 Mar 3. [Content Brief]
- [2]. Li MY, et al. Immunotherapies Targeting Tumor-Associated Macrophages (TAMs) in Cancer. Pharmaceutics. 2024 Jun 27;16(7):865.
- [3]. Hinklin R J, et al. Pyrazolo[3,4-b]pyridine compounds as inhibitors of TAM and MET kinases. WO2020047184A1. WIPO. 2020-03-05.
