1. Protein Tyrosine Kinase/RTK
  2. c-Met/HGFR
  3. Tyrosine kinase inhibitor

Tyrosine kinase inhibitor 

Cat. No.: HY-10421 Purity: 99.36%
Handling Instructions

Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor.

For research use only. We do not sell to patients.

Tyrosine kinase inhibitor Chemical Structure

Tyrosine kinase inhibitor Chemical Structure

CAS No. : 1021950-26-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 123 In-stock
Estimated Time of Arrival: December 31
5 mg USD 95 In-stock
Estimated Time of Arrival: December 31
10 mg USD 145 In-stock
Estimated Time of Arrival: December 31
25 mg USD 290 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Description

Tyrosine kinase inhibitor is a potent tyrosine kinase inhibitor.

In Vitro

Tyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

586.61

Formula

C₃₁H₃₁FN₆O₅

CAS No.

1021950-26-4

SMILES

O=C(NC1=CC=C(C=C1)F)C2(CC2)C(NC3=CC=C(C=C3)OC4=C5C(NC(C(NCCN6CCOCC6)=O)=C5)=NC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 46 mg/mL (78.42 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7047 mL 8.5236 mL 17.0471 mL
5 mM 0.3409 mL 1.7047 mL 3.4094 mL
10 mM 0.1705 mL 0.8524 mL 1.7047 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.26 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Tyrosine kinase inhibitorc-Met/HGFRtyrosinekinasesInhibitorinhibitorinhibit

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Product Name:
Tyrosine kinase inhibitor
Cat. No.:
HY-10421
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