UNC8212
UNC8212 is a TAM kinase inhibitor. UNC8212 has potent inhibitory activity against MERTK and AXL (IC50: 1.5 nM and 1.3 nM, respectively), and also inhibits TYRO3 (IC50: 6.7 nM). UNC8212 mediates polypharmacological properties by targeting the structurally diverse "back pocket" region of the TAM kinase family. UNC8212 binds tightly to TAM kinases and potently inhibits MERTK and AXL phosphorylation. UNC8212 has anti-tumor effects and can be used in cancer immunotherapy and tumor cell targeting research.
For research use only. We do not sell to patients.
- Formula: C34H42N8O3
- Molecular Weight:610.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Axl 1.3 nM (IC50) |
MERTK 1.5 nM (IC50) |
Tyro3 6.7 nM (IC50) |
Chemical Information
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Molecular Weight 610.75
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Formula C34H42N8O3
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SMILES
CC(C)C(NC1=CC(C#CC2=CC=C(NC3=NC(N[C@@H]4CC[C@@H](O)CC4)=C(C(NC5CCN(C)CC5)=O)C=N3)C=C2)=NC=C1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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