Search Result

Results for "

MERTK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Anaplastic lymphoma kinase (ALK) (2) c-Met/HGFR (2) Discoidin Domain Receptor (2) FLT3 (7) ROS Kinase (2) Small Interfering RNA (siRNA) (1) TAM Receptor (4)
By Research Areas:	Cancer (9)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-117548

UNC1062 1 Publications Verification	TAM Receptor	Cancer
UNC1062 is a *MERTK*-selective tyrosine kinase inhibitor, reduces activation of MERTK-mediated downstream signaling, induces apoptosis in culture, reduces colony formation in soft agar, and inhibits invasion of melanoma cells. UNC1062 potently inhibits MERTK kinase activity (MERTK IC₅₀=1.1 nM, Morrison K_i=0.33 nM) and exhibits specificity within the TAM family (TYRO3 IC₅₀=60 nM, AXL IC₅₀=85 nM) .

HY-132200

UNC5293	TAM Receptor Anaplastic lymphoma kinase (ALK) FLT3	Cancer
UNC5293 is a *MERTK*-selective and potent inhibitor (K_i=190 pM). UNC5293 inhibits MERTK (IC₅₀=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research .

HY-12344

UNC2025 2 Publications Verification	FLT3	Cancer
UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC₅₀ values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC₅₀= 122 nM; K_i = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia .

HY-125510

UNC2541 1 Publications Verification	TAM Receptor	Others
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC₅₀ of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC₅₀, 510 nM) .

HY-RS08340

MERTK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MERTK Human Pre-designed siRNA Set A contains three designed siRNAs for MERTK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MERTK Human Pre-designed siRNA Set A MERTK Human Pre-designed siRNA Set A

HY-124502

UNC4203	TAM Receptor FLT3	Cancer
UNC4203 is a potent, orally available and highly selective *MERTK* inhibitor, with IC₅₀s of 1.2 nM, 140 nM, 42 nM and 90 nM for MERTK, AXL, TYRO3 and FLT3, respectively .

HY-101549

MRX-2843 3 Publications Verification UNC2371	FLT3	Cancer
MRX-2843 (UNC2371) is an orally active, ATP-competitive dual *MERTK* and FLT3 tyrosine kinases inhibitor (TKI) with enzymatic IC₅₀s of 1.3 nM for MERTK and 0.64 nM for FLT3, respectively .

HY-12344A

UNC2025 hydrochloride 2 Publications Verification	FLT3	Cancer
UNC2025 hydrochloride is a potent, ATP-competitive, and highly orally active Mer/Flt3 inhibitor with IC₅₀ values of 0.74 nM and 0.8 nM, respectively. UNC2025 hydrochloride is >45-fold selectivity for MERTK relative to Axl (IC₅₀= 122 nM; K_i = 13.3 nM). UNC2025 hydrochloride exhibits an excellent PK properties, and can be used for the investigation of acute leukemia .

HY-15514A

Merestinib dihydrochloride 4 Publications Verification LY2801653 dihydrochloride	c-Met/HGFR FLT3 ROS Kinase Discoidin Domain Receptor	Cancer
Merestinib dihydrochloride (LY2801653 dihydrochloride) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib dihydrochloride also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM) .

HY-15514

Merestinib 4 Publications Verification LY2801653	c-Met/HGFR FLT3 ROS Kinase Discoidin Domain Receptor	Cancer
Merestinib (LY2801653) is a potent, orally bioavailable c-Met inhibitor (K_i=2 nM) with anti-tumor activities. Merestinib (LY2801653) also has potent activity against MST1R (IC₅₀=11 nM), FLT3 (IC₅₀=7 nM), AXL (IC₅₀=2 nM), MERTK (IC₅₀=10 nM), TEK (IC₅₀=63 nM), ROS1, DDR1/2 (IC₅₀=0.1/7 nM) and MKNK1/2 (IC₅₀=7 nM) .

HY-131909

CJ-2360	Anaplastic lymphoma kinase (ALK)	Cancer
CJ-2360 is a potent and orally active ALK inhibitor with IC₅₀s of 2.2, 4.0, 8.8, 6.3, and 8.9 nM against wild-type ALK and F1197M, G1269A, L1196M, and S1206Y ALK mutants, respectively. CJ-2360 displays potent inhibitory activity against two clinically reported ALK mutants (C1156Y and L1196M) and a few other kinases (LTK, MERTK, CLK1, DAPK1, and DAPK2) among the 468 kinases evaluated .

Species:	Human (8) Mouse (3) Rat (1) Cynomolgus (1)
Tag:	His (7) Tag Free (2) GST (2) Fc (4) Flag (1)
Source:	HEK293 (9) Sf9 insect cells (4)

Cat. No.	Compare	Product Name	Species	Source

HY-P78581

	Mer Protein, Cynomolgus (HEK293, Fc) MERTK; Mer	Cynomolgus	HEK293
	Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Mer protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mer Protein, Cynomolgus (HEK293, Fc) is 485 a.a., with molecular weight of approximately 150 kDa.

HY-P78489

	Mer Protein, Human (HEK293, mFc) MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12	Human	HEK293
	Mer Protein, a receptor tyrosine kinase, transduces signals by binding ligands like LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (efferocytosis). Ligand binding induces MERTK autophosphorylation, creating docking sites for downstream molecules. Activated by ligand, Mer interacts with GRB2 or PLCG2, inducing MAPK1, MAPK2, FAK/PTK2, or RAC1 phosphorylation. MERTK signaling is implicated in macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment. In the retinal pigment epithelium (RPE), Mer regulates phagocytosis of rod outer segment fragments. Moreover, Mer inhibits Toll-like receptors (TLRs)-mediated innate immune responses by activating STAT1, inducing SOCS1 and SOCS3 production. Mer Protein, Human (HEK293, mFc) is the recombinant human-derived Mer protein, expressed by HEK293, with C-mFc labeled tag. The total length of Mer Protein, Human (HEK293, mFc) is 485 a.a., with molecular weight of 115-140 kDa.

HY-P73289

	Mer Protein, Mouse (sf9, His-GST) Mer; MERTK; STK kinase; Tyrosine-protein kinase Mer	Mouse	Sf9 insect cells
	Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6. Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding. Mer Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Mer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Mer Protein, Mouse (sf9, His-GST) is 295 a.a., with molecular weight of ~58 kDa.

HY-P73823

	Mer Protein, Human (HEK293, His-Fc) Tyrosine-protein kinase Mer; MERTK; MER	Human	HEK293
	Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (HEK293, His-Fc) is the recombinant human-derived Mer protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of Mer Protein, Human (HEK293, His-Fc) is 479 a.a., with molecular weight of 140-150 kDa.

HY-P73821

	Mer Protein, Human (sf9, His-GST) Tyrosine-protein kinase Mer; MERTK; MER	Human	Sf9 insect cells
	Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (sf9, His-GST) is the recombinant human-derived Mer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Mer Protein, Human (sf9, His-GST) is 295 a.a., with molecular weight of ~50 kDa.

HY-P73820

	Mer Protein, Mouse (HEK293, Fc) Tyrosine-protein kinase Mer; MERTK; MER	Mouse	HEK293
	Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6. Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding. Mer Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Mer protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mer Protein, Mouse (HEK293, Fc) is 498 a.a., with molecular weight of ~130 kDa.

HY-P73824

	Mer Protein, Human (HEK293) Tyrosine-protein kinase Mer; MERTK; MER	Human	HEK293
	Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (HEK293) is the recombinant human-derived Mer protein, expressed by HEK293 , with tag free. The total length of Mer Protein, Human (HEK293) is 479 a.a., with molecular weight of 110-120 kDa.

HY-P73822

	Mer Protein, Human (sf9) Tyrosine-protein kinase Mer; MERTK; MER	Human	Sf9 insect cells
	Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (sf9) is the recombinant human-derived Mer protein, expressed by Sf9 insect cells , with tag free. The total length of Mer Protein, Human (sf9) is 295 a.a., with molecular weight of ~29 kDa.

HY-P700442

	MERTK Protein, Human (HEK293, His) MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MERTK; MER; c-mer; MGC133349	Human	HEK293
	Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. MERTK Protein, Human (HEK293, His) is the recombinant human-derived MERTK protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MERTK Protein, Human (HEK293, His) is 485 a.a., with molecular weight of 55.4 kDa.

HY-P700446

	MERTK Protein, Mouse (HEK293, His) MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MERTK; MER; c-mer; MGC133349	Mouse	HEK293
	Mer Protein, a receptor tyrosine kinase, transduces signals by binding to ligands like LGALS3, TUB, TULP1, or GAS6. Crucial in processes such as cell survival, migration, differentiation, and apoptotic cell phagocytosis, Mer undergoes autophosphorylation upon ligand binding. This creates binding sites for downstream molecules, leading to interactions with GRB2 or PLCG2 and subsequent phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. Mer signaling influences macrophage clearance, platelet aggregation, cytoskeleton reorganization, and engulfment. Notably, in the retinal pigment epithelium, Mer regulates phagocytosis of rod outer segment fragments. Additionally, Mer inhibits the innate immune response triggered by Toll-like receptors (TLRs) by activating STAT1, inducing the production of suppressors of cytokine signaling SOCS1 and SOCS3. MERTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived MERTK protein, expressed by HEK293, with C-10*His labeled tag. The total length of MERTK Protein, Mouse (HEK293, His) is 479 a.a., with molecular weight of 55.0 kDa.

HY-P700594

	MERTK Protein, Rat (HEK293, His) MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MERTK; MER; c-mer; MGC133349	Rat	HEK293
	MERTK Protein, a receptor tyrosine kinase, transmits signals by binding to ligands like LGALS3, TUB, TULP1, or GAS6. Governing cell survival, migration, differentiation, and efferocytosis, MERTK undergoes autophosphorylation upon ligand binding. Docking sites for downstream signaling molecules are created, initiating interactions with GRB2 or PLCG2 and phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. MERTK signaling contributes to diverse processes, including macrophage clearance, platelet aggregation, cytoskeleton reorganization, and engulfment. In the retinal pigment epithelium, MERTK regulates phagocytosis, and it suppresses the innate immune response by activating STAT1 in the Toll-like receptor pathway, promoting the production of SOCS1 and SOCS3. MERTK Protein, Rat (HEK293, His) is the recombinant rat-derived MERTK protein, expressed by HEK293, with N-6*His labeled tag. The total length of MERTK Protein, Rat (HEK293, His) is 479 a.a., with molecular weight of 55.5 kDa.

HY-P702704

	MERTK Protein, Human (Biotinylated, sf9, Flag) MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MERTK; MER; c-mer; MGC133349	Human	Sf9 insect cells

HY-P70958

	Mer Protein, Human (HEK293, His) Tyrosine-protein kinase Mer/Proto-oncogene c-Mer/Receptor tyrosine kinase MERTK/MERTK/MER	Human	HEK293
	MER tyrosine kinase (MERTK) is a transmembrane protein with transmembrane receptor protein tyrosine kinase activity. MERTK has oncogenic properties and is often overexpressed or activated in various malignancies, activating several downstream signaling pathways including MAPK/ERK, PI3K/AKT, and JAK/STAT. MERTK is involved in animal organ development, synapse elimination, neutrophil clearance and protein kinase B signaling. Mer Protein, Human (HEK293, His) is the recombinant human-derived Mer protein, expressed by HEK293, with C-6*His labeled tag. The total length of Mer Protein, Human (HEK293, His) is 323 a.a., with molecular weight of 60-120 kDa.


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Name
Email *

	Sorry, but the email address you supplied was invalid.