1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
  3. UNC2541

UNC2541 

Cat. No.: HY-125510
Handling Instructions

UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM).

For research use only. We do not sell to patients.

UNC2541 Chemical Structure

UNC2541 Chemical Structure

CAS No. : 1612782-86-1

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Description

UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].

IC50 & Target

UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl (IC50, 120 nM), Tyro3 (IC50, 220 nM) and Flt3 (IC50, 320 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (21.21 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1206 mL 10.6029 mL 21.2058 mL
5 mM 0.4241 mL 2.1206 mL 4.2412 mL
10 mM 0.2121 mL 1.0603 mL 2.1206 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

471.57

Formula

C₂₄H₃₄FN₇O₂

CAS No.

1612782-86-1

SMILES

O=C(C(C(NCCCC[[email protected]@H]1N)=N2)=CN=C2NCCCCCCNC1=O)NCC3=CC=C(F)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
UNC2541
Cat. No.:
HY-125510
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UNC2541

Cat. No.: HY-125510