1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
    FLT3
  3. UNC4203

UNC4203 

Cat. No.: HY-124502
Handling Instructions

UNC4203 is a potent, orally available and highly selective MERTK inhibitor, with IC50 of 1.2 nM, 140 nM, 42 nM and 90 nM for MERTK, AXL, TYRO3 and FLT3, respectively.

For research use only. We do not sell to patients.

UNC4203 Chemical Structure

UNC4203 Chemical Structure

CAS No. : 1818234-19-3

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Description

UNC4203 is a potent, orally available and highly selective MERTK inhibitor, with IC50 of 1.2 nM, 140 nM, 42 nM and 90 nM for MERTK, AXL, TYRO3 and FLT3, respectively[1].

In Vivo

Mice are treated with UNC4203 (compound 24) at a dose of 10 mg/kg administered via oral (po) or iv routes. Under the condition, UNC4203 (compound 24) has 58% oral bioavailability with a 7.8 h half-life, 1.7 L/kg volume of distribution, and 36 mL/min/kg clearance[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

504.71

Formula

C₃₀H₄₄N₆O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Product Name:
UNC4203
Cat. No.:
HY-124502
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