1. Protein Tyrosine Kinase/RTK
  2. FLT3

UNC2025 

Cat. No.: HY-12344 Purity: 99.97%
Handling Instructions

UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3.

For research use only. We do not sell to patients.

UNC2025 Chemical Structure

UNC2025 Chemical Structure

CAS No. : 1429881-91-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 86 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 78 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 132 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg USD 540 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
100 mg USD 1020 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of UNC2025:

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

UNC2025 is a potent and orally bioavailable Mer/Flt3 dual inhibitor with IC50 of 0.8/0.74 nM for Mer/Flt3. IC50 value: 0.8/0.74 nM(MER/FLT3) Target: Mer/Flt3 inhibitor UNC2025 was capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome pro ling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that 11 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined.

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.0979 mL 10.4897 mL 20.9793 mL
5 mM 0.4196 mL 2.0979 mL 4.1959 mL
10 mM 0.2098 mL 1.0490 mL 2.0979 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

476.66

Formula

C₂₈H₄₀N₆O

CAS No.

1429881-91-3

SMILES

CN1CCN(CC2=CC=C(C3=CN([[email protected]@H]4CC[[email protected]@H](O)CC4)C5=NC(NCCCC)=NC=C53)C=C2)CC1

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: 33.33 mg/mL; H2O: < 4.9 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Inquiry Information

Product Name:
UNC2025
Cat. No.:
HY-12344
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