1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
    ALK
    FLT3
  3. UNC5293

UNC5293 

Cat. No.: HY-132200
Handling Instructions

UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research.

For research use only. We do not sell to patients.

UNC5293 Chemical Structure

UNC5293 Chemical Structure

CAS No. : 2226789-82-6

Size Price Stock
5 mg USD 480 Ask For Quote & Lead Time
10 mg USD 800 Ask For Quote & Lead Time
25 mg USD 1650 Ask For Quote & Lead Time
50 mg USD 2600 Ask For Quote & Lead Time
100 mg USD 4000 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research[1].

IC50 & Target

Ki: 190 pM (MERTK)
IC50: 0.9 nM (MERTK)[1]

In Vitro

UNC5293 provides selective target inhibition in cell-based assays. In cultures of the human B-cell acute lymphoblastic leukemia (B-ALL) cell line, UNC5293 inhibits phosphorylation of MERTK with an IC50 of 9.4 nM. In the SEM B-ALL cell line, UNC5293 is less potent against FLT3, with an IC50 of 170 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

UNC5293 (oral administration; 120 mg/kg; single dose) effectively inhibit MERTK in vivo in orthotopic 697 B-ALL mice xenografts[1].
UNC5293 (oral gavage; 3 mg/kg; single dose) has excellent mouse PK properties (7.8 h half-life and 58% oral bioavailability), and the Cmax and AUClast are 9.2 μM and 2.5 h*μM, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

518.69

Formula

C₃₀H₄₂N₆O₂

CAS No.
SMILES

O=C(C1=CC(C)=NC(C)=C1)N2CCC(C3=CN([[email protected]]4CC[[email protected]](O)CC4)C5=NC(N[[email protected]@H](C)CCC)=NC=C53)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

UNC5293UNC 5293UNC-5293TAM ReceptorALKFLT3Tyro3AxlMerAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3MERTKCancerimmunotherapyFlt3bone marrowleukemiaInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
UNC5293
Cat. No.:
HY-132200
Quantity:
MCE Japan Authorized Agent: