1. Recombinant Proteins
  2. Receptor Proteins Enzymes & Regulators
  3. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  4. TAM Receptor
  5. TYRO3
  6. TYRO3/DTK Protein, Mouse (HEK293, His)

TYRO3/DTK Protein, Mouse (HEK293, His)

Cat. No.: HY-P77863
Handling Instructions

TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation. Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules. TYRO3/DTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-His labeled tag. The total length of TYRO3/DTK Protein, Mouse (HEK293, His) is 389 a.a., with molecular weight of 60-75 kDa.

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Description

TYRO3/DTK protein is a receptor tyrosine kinase that transduces signals through ligands such as TULP1 or GAS6 to regulate cell survival, migration and differentiation. Ligand binding induces TYRO3 dimerization and autophosphorylation, creating docking sites for downstream molecules. TYRO3/DTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived TYRO3/DTK protein, expressed by HEK293 , with C-His labeled tag. The total length of TYRO3/DTK Protein, Mouse (HEK293, His) is 389 a.a., with molecular weight of 60-75 kDa.

Background

The TYRO3/DTK protein, a receptor tyrosine kinase, transduces signals from the extracellular matrix by binding to various ligands, including TULP1 or GAS6. It plays a crucial role in regulating numerous physiological processes, encompassing cell survival, migration, and differentiation. Upon ligand binding at the cell surface, TYRO3 undergoes dimerization and autophosphorylation on its intracellular domain, creating docking sites for downstream signaling molecules. Upon activation, TYRO3 interacts with PIK3R1, enhancing PI3-kinase activity and activating the AKT survival pathway, leading to nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling is implicated in processes such as neuron protection from excitotoxic injury, platelet aggregation, and cytoskeleton reorganization. Additionally, TYRO3 plays a crucial role in inhibiting Toll-like receptors (TLRs)-mediated innate immune responses by activating STAT1, which selectively induces the production of suppressors of cytokine signaling SOCS1 and SOCS3.

Species

Mouse

Source

HEK293

Tag

C-His

Accession

P55144-2 (R31-D419)

Gene ID

22174  [NCBI]

Molecular Construction
N-term
TYRO3 (R31-D419)
Accession # P55144-2
His
C-term
Synonyms
BYK; DTK; RSE; SKY; TIF; TYRO3; Brt; Rse
Molecular Weight

60-75 kDa

Purity

Greater than 95% as determined by Tris-Bis PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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TYRO3/DTK Protein, Mouse (HEK293, His)
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HY-P77863
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