1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
  3. LDC1267

LDC1267 

Cat. No.: HY-12494 Purity: 99.84%
Handling Instructions

LDC1267 is a highly selective TAM (Tyro3, Axl and Mer) kinase inhibitor with IC50s of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively[1].

For research use only. We do not sell to patients.

LDC1267 Chemical Structure

LDC1267 Chemical Structure

CAS No. : 1361030-48-9

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 99 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 290 In-stock
Estimated Time of Arrival: December 31
100 mg USD 490 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 4 publication(s) in Google Scholar

Top Publications Citing Use of Products

    LDC1267 purchased from MCE. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278.

    BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of RTKs (Dovitinib at 1 µM, Gefinitib at 2.5 µM, Sunitinib at 2.5 µM and LDC1267 at 1 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.

    LDC1267 purchased from MCE. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278.

    BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of TAM receptor (LDC1267 at 1 µM, UNC2250 at 5 µM, R428 at 5 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    LDC1267 is a highly selective TAM (Tyro3, Axl and Mer) kinase inhibitor with IC50s of <5 nM/8 nM/29 nM for Tyro3,Axl and Mer respectively[1].

    IC50 & Target

    IC50: <5 nM/8 nM/29 nM(Tyro3/Axl/Mer)[1]

    In Vitro

    LDC1267 (up to 30 µM; 72 hours) moderately affectes proliferation of 11 cell lines with an average IC50 value for those 11 cell lines is ~15µM[1].

    In Vivo

    LDC1267 (20 mg/kg; i.p.; every 12 hours for 14 day) markedly reduces metastatic spreading of melanomas[1].

    Animal Model: C57BL/6J wild type mice (8-12 weeks old syngeneic bearing B16F10 cells)[1]
    Dosage: 20mg/kg
    Administration: Intraperitoneal injection; every 12 hours for 14 days
    Result: Markedly reduced metastatic spreading of melanomas.
    Molecular Weight

    560.55

    Formula

    C₃₀H₂₆F₂N₄O₅

    CAS No.

    1361030-48-9

    SMILES

    FC1=CC(NC(C2=NN(C3=CC=C(F)C=C3C)C=C2OCC)=O)=CC=C1OC4=CC=NC5=CC(OC)=C(OC)C=C54

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (89.20 mM; Need ultrasonic)

    H2O : < 0.1 mg/mL (insoluble)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.7840 mL 8.9198 mL 17.8396 mL
    5 mM 0.3568 mL 1.7840 mL 3.5679 mL
    10 mM 0.1784 mL 0.8920 mL 1.7840 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (4.46 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: 2.5 mg/mL (4.46 mM); Suspended solution; Need ultrasonic

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (4.46 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
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    Keywords:

    LDC1267LDC 1267LDC-1267TAM ReceptorTyro3AxlMerInhibitorinhibitorinhibit

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    Product name:
    LDC1267
    Cat. No.:
    HY-12494
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