1. Protein Tyrosine Kinase/RTK
    Apoptosis
  2. TAM Receptor
    Apoptosis
  3. Dubermatinib

Dubermatinib (Synonyms: TP-0903)

Cat. No.: HY-12963 Purity: 99.53%
Handling Instructions

Dubermatinib (TP-0903) is a potent and selective Axl receptor tyrosine kinase inhibitor with an IC50 value of 27 nM.

For research use only. We do not sell to patients.

Dubermatinib Chemical Structure

Dubermatinib Chemical Structure

CAS No. : 1341200-45-0

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10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
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10 mg USD 100 In-stock
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50 mg USD 290 In-stock
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100 mg USD 450 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Publications Citing Use of MCE Dubermatinib

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  • Customer Review

Description

Dubermatinib (TP-0903) is a potent and selective Axl receptor tyrosine kinase inhibitor with an IC50 value of 27 nM.

IC50 & Target

IC50: 27nM (Axl)[1]

In Vitro

Dubermatinib (TP-0903) displays a potent activity against AXL with an IC50 of 0.027 μM. Dubermatinib (TP-0903) shows extremely potent activity in cell viability assays with an IC50 of 6 nM against the pancreatic cancer cell line PSN-1. Dubermatinib (TP-0903) is evaluated for its ability to block GAS6-mediated activation of AXL in pancreatic cancer cells. PSN-1 cells are serum-starved and then stimulated with GAS6 in the presence of various concentrations of TP-0903[1].

Clinical Trial
Molecular Weight

516.06

Formula

C₂₄H₃₀ClN₇O₂S

CAS No.

1341200-45-0

SMILES

O=S(C1=CC=CC=C1NC2=NC(NC3=CC=C(CN4CCN(C)CC4)C=C3)=NC=C2Cl)(N(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (9.69 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9378 mL 9.6888 mL 19.3776 mL
5 mM 0.3876 mL 1.9378 mL 3.8755 mL
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  0.5% CMC-Na/saline water

    Solubility: 10 mg/mL (19.38 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

For cell proliferation assays, 45 μL containing 1000 cells per well are seeded into solid white 384-well plates in appropriate media. The following day, Dubermatinib (TP-0903) is diluted in serum free growth media to 10x desired concentrations and 5 μL is added to each well. Combined compound and cells are incubated for 96 hours. Following incubation, 40 μL of ATP-Lite solution is added to each well, incubated for an additional 10 minutes at room temperature and luminescence is measured on an microplate reader[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: 99.53%

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Keywords:

DubermatinibTP-0903TP0903TP 0903TAM ReceptorApoptosisTyro3AxlMerInhibitorinhibitorinhibit

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