1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
  3. UNC2250

UNC2250 

Cat. No.: HY-15797 Purity: 99.96%
Handling Instructions

UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

For research use only. We do not sell to patients.

UNC2250 Chemical Structure

UNC2250 Chemical Structure

CAS No. : 1493694-70-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO USD 77 In-stock
Estimated Time of Arrival: December 31
5 mg USD 70 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
50 mg USD 440 In-stock
Estimated Time of Arrival: December 31
100 mg USD 740 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE UNC2250

    UNC2250 purchased from MCE. Usage Cited in: Theranostics. 2018 Jul 30;8(15):4262-4278.

    BV2 cells are pretreated with 0.1% DMSO (Ctrl), JuA (25 µM) or JuA (25 µM) with the indicated antagonist of TAM receptor (LDC1267 at 1 µM, UNC2250 at 5 µM, R428 at 5 µM) for 30 min, followed by administration of Aβ42 (5 μM) for 12 h.
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.

    IC50 & Target

    IC50: 1.7 nM (Mer)[1]

    In Vitro

    UNC2250 (5-500 nM; 1 hour) inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM[1].
    UNC2250 efficiently inhibits ligand-dependent phosphorylation of a chimeric protein consisting of the extracellular and transmembrane domains of the epidermal growth factor (EGF) receptor and the intracellular tyrosine kinase domain of Mer[1].
    UNC2250 incubation inhibits colony formation in soft agar cultures of the BT-12 rhabdoid tumor and the Colo699 NSCLC cell lines[1] .

    Western Blot Analysis[1]

    Cell Line: 697 B-ALL cells
    Concentration: 5, 10, 20, 50, 100, 250, 500 nM
    Incubation Time: 1 hour
    Result: Inhibits Mer phosphorylation in 697 B-ALL cells with an IC50 value of 9.8 nM.
    Molecular Weight

    440.58

    Formula

    C₂₄H₃₆N₆O₂

    CAS No.

    1493694-70-4

    SMILES

    CCCCNC1=NC(N[[email protected]@H]2CC[[email protected]@H](O)CC2)=C(C3=CC=C(CN4CCOCC4)C=N3)C=N1

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage
    Powder -20°C 3 years
      4°C 2 years
    In solvent -80°C 6 months
      -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 20 mg/mL (45.39 mM; ultrasonic and warming and heat to 60°C)

    0.1 M HCL : 12.5 mg/mL (28.37 mM; ultrasonic and adjust pH to 3 with HCl)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2697 mL 11.3487 mL 22.6974 mL
    5 mM 0.4539 mL 2.2697 mL 4.5395 mL
    10 mM 0.2270 mL 1.1349 mL 2.2697 mL
    *Please refer to the solubility information to select the appropriate solvent.
    References
    • No file chosen (Maximum size is: 1024 Kb)
    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.
    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    UNC2250UNC 2250UNC-2250TAM ReceptorTyro3AxlMerInhibitorinhibitorinhibit

    Your Recently Viewed Products:

    Inquiry Online

    Your information is safe with us. * Required Fields.

    Product name

     

    Salutation

    Applicant name *

     

    Email address *

    Phone number *

     

    Organization name *

    Country or Region *

     

    Requested quantity *

    Remarks

    Bulk Inquiry

    Inquiry Information

    Product name:
    UNC2250
    Cat. No.:
    HY-15797
    Quantity:
    MCE Japan Authorized Agent: