2. Recombinant Proteins
  3. Receptor Proteins Enzymes & Regulators
  4. Receptor Tyrosine Kinases Protein Tyrosine Kinases
  5. TAM Receptor
  6. Mer Proteins

Mer Proteins

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Cat. No. Product Name / Synonyms Species Source
  • HY-P70958
    Mer Protein, Human (HEK293, His)

    Tyrosine-protein kinase Mer/Proto-oncogene c-Mer/Receptor tyrosine kinase MerTK/MERTK/MER

    		Human HEK293
    MER tyrosine kinase (MERTK) is a transmembrane protein with transmembrane receptor protein tyrosine kinase activity. MERTK has oncogenic properties and is often overexpressed or activated in various malignancies, activating several downstream signaling pathways including MAPK/ERK, PI3K/AKT, and JAK/STAT. MERTK is involved in animal organ development, synapse elimination, neutrophil clearance and protein kinase B signaling. Mer Protein, Human (HEK293, His) is the recombinant human-derived Mer protein, expressed by HEK293, with C-6*His labeled tag. The total length of Mer Protein, Human (HEK293, His) is 323 a.a., with molecular weight of 60-120 kDa.
  • HY-P78581
    Mer Protein, Cynomolgus (HEK293, Fc)

    MERTK; Mer

    		Cynomolgus HEK293
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived Mer protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mer Protein, Cynomolgus (HEK293, Fc) is 485 a.a., with molecular weight of approximately 150 kDa.
  • HY-P73289
    Mer Protein, Mouse (sf9, His-GST)

    Mer; MerTK; STK kinase; Tyrosine-protein kinase Mer

    		Mouse Sf9 insect cells
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6. Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding. Mer Protein, Mouse (sf9, His-GST) is the recombinant mouse-derived Mer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Mer Protein, Mouse (sf9, His-GST) is 295 a.a., with molecular weight of ~58 kDa.
  • HY-P700442
    MERTK Protein, Human (HEK293, His)

    MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; MER; c-mer; MGC133349;

    		Human HEK293
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. MERTK Protein, Human (HEK293, His) is the recombinant human-derived MERTK protein, expressed by HEK293 , with C-10*His labeled tag. The total length of MERTK Protein, Human (HEK293, His) is 485 a.a., with molecular weight of 55.4 kDa.
  • HY-P700446
    MERTK Protein, Mouse (HEK293, His)

    MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; MER; c-mer; MGC133349;

    		Mouse HEK293
    Mer Protein, a receptor tyrosine kinase, transduces signals by binding to ligands like LGALS3, TUB, TULP1, or GAS6. Crucial in processes such as cell survival, migration, differentiation, and apoptotic cell phagocytosis, Mer undergoes autophosphorylation upon ligand binding. This creates binding sites for downstream molecules, leading to interactions with GRB2 or PLCG2 and subsequent phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. Mer signaling influences macrophage clearance, platelet aggregation, cytoskeleton reorganization, and engulfment. Notably, in the retinal pigment epithelium, Mer regulates phagocytosis of rod outer segment fragments. Additionally, Mer inhibits the innate immune response triggered by Toll-like receptors (TLRs) by activating STAT1, inducing the production of suppressors of cytokine signaling SOCS1 and SOCS3. MERTK Protein, Mouse (HEK293, His) is the recombinant mouse-derived MERTK protein, expressed by HEK293, with C-10*His labeled tag. The total length of MERTK Protein, Mouse (HEK293, His) is 479 a.a., with molecular weight of 55.0 kDa.
  • HY-P73820
    Mer Protein, Mouse (HEK293, Fc)

    Tyrosine-protein kinase Mer; MERTK; MER

    		Mouse HEK293
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1 or GAS6. Mer is critical in processes such as cell survival, migration, differentiation, and phagocytosis of apoptotic cells, and autophosphorylation occurs upon ligand binding. Mer Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Mer protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Mer Protein, Mouse (HEK293, Fc) is 498 a.a., with molecular weight of ~130 kDa.
  • HY-P73821
    Mer Protein, Human (sf9, His-GST)

    Tyrosine-protein kinase Mer; MERTK; MER

    		Human Sf9 insect cells
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (sf9, His-GST) is the recombinant human-derived Mer protein, expressed by Sf9 insect cells , with N-His, N-GST labeled tag. The total length of Mer Protein, Human (sf9, His-GST) is 295 a.a., with molecular weight of ~50 kDa.
  • HY-P73823
    Mer Protein, Human (HEK293, His-Fc)

    Tyrosine-protein kinase Mer; MERTK; MER

    		Human HEK293
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (HEK293, His-Fc) is the recombinant human-derived Mer protein, expressed by HEK293 , with C-hFc, C-His labeled tag. The total length of Mer Protein, Human (HEK293, His-Fc) is 479 a.a., with molecular weight of 140-150 kDa.
  • HY-P78489
    Mer Protein, Human (HEK293, mFc)

    MERTK; MER; c-Eyk; MGC133349; c-mer; RP38; Tyro12

    		Human HEK293
    Mer Protein, a receptor tyrosine kinase, transduces signals by binding ligands like LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (efferocytosis). Ligand binding induces MERTK autophosphorylation, creating docking sites for downstream molecules. Activated by ligand, Mer interacts with GRB2 or PLCG2, inducing MAPK1, MAPK2, FAK/PTK2, or RAC1 phosphorylation. MERTK signaling is implicated in macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization, and engulfment. In the retinal pigment epithelium (RPE), Mer regulates phagocytosis of rod outer segment fragments. Moreover, Mer inhibits Toll-like receptors (TLRs)-mediated innate immune responses by activating STAT1, inducing SOCS1 and SOCS3 production. Mer Protein, Human (HEK293, mFc) is the recombinant human-derived Mer protein, expressed by HEK293, with C-mFc labeled tag. The total length of Mer Protein, Human (HEK293, mFc) is 485 a.a., with molecular weight of 115-140 kDa.
  • HY-P73822
    Mer Protein, Human (sf9)

    Tyrosine-protein kinase Mer; MERTK; MER

    		Human Sf9 insect cells
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (sf9) is the recombinant human-derived Mer protein, expressed by Sf9 insect cells , with tag free. The total length of Mer Protein, Human (sf9) is 295 a.a., with molecular weight of ~29 kDa.
  • HY-P73824
    Mer Protein, Human (HEK293)

    Tyrosine-protein kinase Mer; MERTK; MER

    		Human HEK293
    Mer protein is a receptor tyrosine kinase that transduces signals by binding to ligands such as LGALS3, TUB, TULP1, or GAS6, regulating cell survival, migration, differentiation, and apoptotic cell phagocytosis (endocytosis). Ligand binding induces autophosphorylation of MERTK, creating a docking site for downstream molecules. Mer Protein, Human (HEK293) is the recombinant human-derived Mer protein, expressed by HEK293 , with tag free. The total length of Mer Protein, Human (HEK293) is 479 a.a., with molecular weight of 110-120 kDa.
  • HY-P700594
    MERTK Protein, Rat (HEK293, His)

    MERTK; c-mer proto-oncogene tyrosine kinase; tyrosine-protein kinase Mer; mer; RP38; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; MER; c-mer; MGC133349;

    		Rat HEK293
    MERTK Protein, a receptor tyrosine kinase, transmits signals by binding to ligands like LGALS3, TUB, TULP1, or GAS6. Governing cell survival, migration, differentiation, and efferocytosis, MERTK undergoes autophosphorylation upon ligand binding. Docking sites for downstream signaling molecules are created, initiating interactions with GRB2 or PLCG2 and phosphorylation of MAPK1, MAPK2, FAK/PTK2, or RAC1. MERTK signaling contributes to diverse processes, including macrophage clearance, platelet aggregation, cytoskeleton reorganization, and engulfment. In the retinal pigment epithelium, MERTK regulates phagocytosis, and it suppresses the innate immune response by activating STAT1 in the Toll-like receptor pathway, promoting the production of SOCS1 and SOCS3. MERTK Protein, Rat (HEK293, His) is the recombinant rat-derived MERTK protein, expressed by HEK293, with N-6*His labeled tag. The total length of MERTK Protein, Rat (HEK293, His) is 479 a.a., with molecular weight of 55.5 kDa.
Cat. No. Product Name Effect Purity