2. Anti-infection NF-κB Immunology/Inflammation Apoptosis
  3. Bacterial NF-κB Toll-like Receptor (TLR) Apoptosis
  4. Juglone

Juglone  (Synonyms: 5-Hydroxy-1,4-naphthalenedione)

Cat. No.: HY-N6949 Purity: 97.45%
COA Handling Instructions

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Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity .

For research use only. We do not sell to patients.

Juglone Chemical Structure

Juglone Chemical Structure

CAS No. : 481-39-0

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Based on 2 publication(s) in Google Scholar

Juglone Related Antibodies

Top Publications Citing Use of Products

View All NF-κB Isoform Specific Products:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

View All Toll-like Receptor (TLR) Isoform Specific Products:

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Juglone (5-hydroxy-1,4-naphthalenedione) is a yellow dye that can be extracted from Juglans regia. Juglone induces apoptosis through the mitochondrial pathway. Juglone has antibacterial and antitumor activity [1][2][3].

In Vitro

Juglone (0-500 μg/mL, 15 h) shows significant antibacterial activity against Staphylococcus aureus, with MIC values ranging from 64-512 μg/mL[1].
Juglone(5-20 μM, 24 h) induces apoptosis of SGC-7901 cells through the mitochondrial pathway mediated by ROS production and the decrease of Bcl-2/Bax ratio[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Juglone Related Antibodies

Cell Cytotoxicity Assay [2]

Cell Line: SGC-7901
Concentration: 5, 10, 15, 20 μM
Incubation Time: 24 h
Result: Inhibited cell growth in a dose-dependent manner.

Apoptosis Analysis [2]

Cell Line: SGC-7901
Concentration: 5, 10, 15, 20 μM
Incubation Time: 24 h
Result: Increased the number of early apoptotic cells.

Western Blot Analysis [2]

Cell Line: SGC-7901
Concentration: 5, 10, 15, 20 μM
Incubation Time: 24 h
Result: Decreased the expression of Bcl-2 and increased the Bax protein.
In Vivo

Juglone (0.25 or 1 mg/kg, oral, 70 days) prevents metabolic endotoxemia-nduced hepatitis and neuroinflammation by inhibiting TLR4/NF-kB signaling pathway in high-fat diet rats[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet rats model[3]
Dosage: 0.25 or 1 mg/kg
Administration: p.o. for 70 days
Result: Regulated the expression of s TNF-α, IL-1β and IL-6.
Inhibited the TLR4 expression and NF-kappa activity.
Molecular Weight

174.16

Formula

C10H6O3
CAS No.
Appearance

Solid

Color

Brown to orange

SMILES

O=C(C1=C2C=CC=C1O)C=CC2=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

Ethanol : 10 mg/mL (57.42 mM; Need ultrasonic; DMSO can inactivate Juglone's activity)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7418 mL 28.7092 mL 57.4185 mL
5 mM 1.1484 mL 5.7418 mL 11.4837 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 97.45%

COA (253 KB) HNMR (235 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol 1 mM 5.7418 mL 28.7092 mL 57.4185 mL 143.5462 mL
5 mM 1.1484 mL 5.7418 mL 11.4837 mL 28.7092 mL
10 mM 0.5742 mL 2.8709 mL 5.7418 mL 14.3546 mL
15 mM 0.3828 mL 1.9139 mL 3.8279 mL 9.5697 mL
20 mM 0.2871 mL 1.4355 mL 2.8709 mL 7.1773 mL
25 mM 0.2297 mL 1.1484 mL 2.2967 mL 5.7418 mL
30 mM 0.1914 mL 0.9570 mL 1.9139 mL 4.7849 mL
40 mM 0.1435 mL 0.7177 mL 1.4355 mL 3.5887 mL
50 mM 0.1148 mL 0.5742 mL 1.1484 mL 2.8709 mL
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Juglone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Juglone481-39-05-Hydroxy-1,4-naphthalenedioneBacterialNF-κBToll-like Receptor (TLR)ApoptosisNuclear factor-κBNuclear factor-kappaBYellowPigmentblackwalnutantimicrobialInhibitorinhibitorinhibit

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