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HA15 

Cat. No.: HY-100437 Purity: 99.82%
Data Sheet SDS Handling Instructions

HA15 is a molecule that targets specifically BiP/GRP78/HSPA5.

For research use only. We do not sell to patients.
HA15 Chemical Structure

HA15 Chemical Structure

CAS No. : 1609402-14-3

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply now  
10 mM * 1 mL in DMSO $88 In-stock
5 mg $80 In-stock
10 mg $110 In-stock
50 mg $350 In-stock
100 mg $600 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

HA15 is a molecule that targets specifically BiP/GRP78/HSPA5 target: BiP, GRP78, HSPA5 [1] In vitro: HA15 induces ER stress leading to cancer cell death. kills cancer cells by targeting BiP to increase ER stress, leading to melanoma cell death by concomitant induction of autophagic and apoptotic mechanisms. HA15 exhibits strong efficacy in melanoma cells. The 50% inhibitory concentration (IC50) in A375 cells was between 1 and 2.5 mM HA15. [1] In vivo: HA15 induces ER stress leading to cancer cell death. HA15 also exhibited strong efficacy in xenograft mouse models with melanoma cells either sensitive or resistant to BRAF inhibitors. [1]

References
Preparing Stock Solutions
Concentration Volume Mass 1 mg 5 mg 10 mg
1 mM 2.1433 mL 10.7163 mL 21.4326 mL
5 mM 0.4287 mL 2.1433 mL 4.2865 mL
10 mM 0.2143 mL 1.0716 mL 2.1433 mL
Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

466.58

Formula

C₂₃H₂₂N₄O₃S₂

CAS No.

1609402-14-3

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

10 mM in DMSO

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
HA15
Cat. No.:
HY-100437
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