1. Epigenetics
  2. Protein Arginine Deiminase
  3. BB-Cl-Amidine

BB-Cl-Amidine 

Cat. No.: HY-111347
Handling Instructions

BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor.

For research use only. We do not sell to patients.

BB-Cl-Amidine Chemical Structure

BB-Cl-Amidine Chemical Structure

CAS No. : 1802637-39-3

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1 mg USD 50 Get quote
5 mg USD 95 Get quote
10 mg USD 170 Get quote
25 mg USD 360 Get quote

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Description

BB-Cl-Amidine is a peptidylarginine deminase (PAD) inhibitor.

IC50 & Target

PAD[1].

In Vivo

Treatment with BB-Cl-amidine subtly reduces splenomegaly in MRL/lpr mice, while there is a trend towards increased circulating levels of anti-NET antibodies with PAD inhibitor treatment. However, neither PAD inhibitor affected body weight or total IgG levels. Indeed, treatment with both Cl-amidine and BB-Cl-amidine significantly improves endothelium-dependent vasorelaxation. The BB-Cl-amidine group also shows a strong trend towards downregulation of IRGs. Treatment with either Cl-amidine or BB-Cl-amidine significantly improves muzzle alopecia, in many cases preventing it entirely[1].

Animal Model: MRL/lpr mice[1].
Dosage: 1 mg/kg.
Administration: Subcutaneous injection daily from 8 to 14 weeks of age.
Result: Significantly improved endothelium-dependent vasorelaxation and showed a strong trend towards downregulation of IRGs.
Molecular Weight

459.97

Formula

C₂₆H₂₆ClN₅O

CAS No.

1802637-39-3

SMILES

O=C(C1=CC=C(C2=CC=CC=C2)C=C1)N[[email protected]](C3=NC4=CC=CC=C4N3)CCCNC(CCl)=N

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (271.76 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1741 mL 10.8703 mL 21.7405 mL
5 mM 0.4348 mL 2.1741 mL 4.3481 mL
10 mM 0.2174 mL 1.0870 mL 2.1741 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (4.52 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (4.52 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (4.52 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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BB-Cl-Amidine
Cat. No.:
HY-111347
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