1. Epigenetics
  2. Protein Arginine Deiminase
  3. BMS-P5 free base

BMS-P5 free base 

Cat. No.: HY-137655A Purity: 99.94%
Handling Instructions

BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 free base blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model.

For research use only. We do not sell to patients.

BMS-P5 free base Chemical Structure

BMS-P5 free base Chemical Structure

CAS No. : 1550371-22-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 520 In-stock
Estimated Time of Arrival: December 31
5 mg USD 500 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
50 mg USD 3000 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

BMS-P5 free base is a specific and orally active peptidylarginine deiminase 4 (PAD4) inhibitor. BMS-P5 free base blocks MM-induced NET formation and delays progression of MM in a syngeneic mouse model[1].

In Vitro

BMS-P5 blocks calcium ionophore-induced citrullination of histone H3[1].
BMS-P5 is also able to inhibit formation of NETs induced by primary MM cells isolated from the BM of patients with MM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1].

Cell Line: Neutrophils.
Concentration: 10 µM and 100 µM.
Incubation Time: 30 min followed by addition of DP42 or 5TGM1 CM.
Result: Prevented MM-induced NET formation.
In Vivo

BMS-P5 (50 mg/kg, oral gavage) significantly improves survival of MM-bearing mice[1].
BMS-P5 (50 mg/kg, oral gavage) may attenuate the presence of pro-tumorigenic proteins in the tumor microenvironment, and thus delay tumor progression[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Syngeneic mouse model of MM[1].
Dosage: 50 mg/kg.
Administration: Oral gavage, twice a day beginning on day 3 after tumor cell injection.
Result: Significantly delayed development of symptoms and significantly prolonged survival of MM-bearing mice.
Molecular Weight

472.58

Formula

C₂₇H₃₂N₆O₂

CAS No.

1550371-22-6

SMILES

O=C(N1[[email protected]@H](C)CC[[email protected]@H](N)C1)C2=CC(OC)=C3C(N=C(C4=CC5=CC=CN=C5N4CC6CC6)N3C)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (529.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1160 mL 10.5802 mL 21.1604 mL
5 mM 0.4232 mL 2.1160 mL 4.2321 mL
10 mM 0.2116 mL 1.0580 mL 2.1160 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 25 mg/mL (52.90 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 25 mg/mL (52.90 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 25 mg/mL (52.90 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BMS-P5Protein Arginine DeiminasePeptidylarginine DeiminaseMultiplemyelomaNETInhibitorinhibitorinhibit

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BMS-P5 free base
Cat. No.:
HY-137655A
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