1. Epigenetics
    Apoptosis
  2. Protein Arginine Deiminase
    Apoptosis
  3. D-Cl-amidine hydrochloride

D-Cl-amidine hydrochloride 

Cat. No.: HY-100574D Purity: 99.40%
Handling Instructions

D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.

For research use only. We do not sell to patients.

D-Cl-amidine hydrochloride Chemical Structure

D-Cl-amidine hydrochloride Chemical Structure

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Free Sample (0.5-1 mg)   Apply Now  
5 mg USD 250 In-stock
Estimated Time of Arrival: December 31
10 mg USD 380 In-stock
Estimated Time of Arrival: December 31
25 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1200 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1800 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of D-Cl-amidine hydrochloride:

Top Publications Citing Use of Products
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Description

D-Cl-amidine hydrochloride is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].

In Vitro

D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells[1].
D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

347.24

Formula

C₁₄H₂₀Cl₂N₄O₂

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 80 mg/mL (230.39 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8799 mL 14.3993 mL 28.7985 mL
5 mM 0.5760 mL 2.8799 mL 5.7597 mL
10 mM 0.2880 mL 1.4399 mL 2.8799 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.67 mg/mL (7.69 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.67 mg/mL (7.69 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.67 mg/mL (7.69 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Product Name:
D-Cl-amidine hydrochloride
Cat. No.:
HY-100574D
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