1. Epigenetics
    Apoptosis
  2. Protein Arginine Deiminase
    Apoptosis
  3. D-Cl-amidine

D-Cl-amidine 

Cat. No.: HY-100574C
Handling Instructions

D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity.

For research use only. We do not sell to patients.

D-Cl-amidine Chemical Structure

D-Cl-amidine Chemical Structure

CAS No. : 1404060-15-6

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Description

D-Cl-amidine is a potent and highly selective PAD1 inhibitor. D-Cl-amidine is well-torelated with no significant toxicity[1].

In Vitro

D-Cl-amidine (200-400 μM) is effective in significantly decreasing cell viability in MDA-MB-231 cells[1].
D-Cl-amidine increase caspase 3 activity, indicating that inhibition of PAD1 leads to an increase in apoptosis[1].

In Vivo

D-Cl-amidine, administered by iv at a dose of 2.5 mg/kg, is still detected after 2 h in serum at a concentration of ~21 nM and at 4 h at ~10 nM. D-Cl-amidine is still observed in the blood serum at a concentration of ∼10 nM at 4 h when administered by ip at a dose of 10 mg/kg[1].

Molecular Weight

310.78

Formula

C₁₄H₁₉ClN₄O₂

CAS No.

1404060-15-6

SMILES

O=C(N[[email protected]@H](C(N)=O)CCCNC(CCl)=N)C1=CC=CC=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

D-Cl-amidineProtein Arginine DeiminaseApoptosisPeptidylarginine Deiminasetriple-negative breast cancerMDA-MB-231TNBCInhibitorinhibitorinhibit

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D-Cl-amidine
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