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製品番号: HY-181449

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CAY10729

CAY10729 (Compound 21) is a selective PAD2 inhibitor. CAY10729 inhibits neutrophil extracellular trap formation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
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CAS 番号: 1644666-57-8
分子式: C₁₉H₂₆ClN₇O₃
分子量:435.91

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CAY10729 構造式

CAS 番号: 1644666-57-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

CAY10729 (Compound 21) is a selective PAD2 inhibitor. CAY10729 inhibits neutrophil extracellular trap formation^[1].

IC₅₀ & Target^[1]

PAD2

Cellular Effect

Cell Line	Type	Value	Description	References
Neutrophil	EC₅₀	985 μM Compound: 21	Cytotoxicity against human neutrophils assessed as cell viability after 4 hrs by XTT assay Cytotoxicity against human neutrophils assessed as cell viability after 4 hrs by XTT assay	[PMID: 25559347]

体外実験

CAY10729 (1-500 μM; 4 h) exhibits extremely low cytotoxicity toward neutrophils, with an EC₅₀ of 985 μM^[1].
CAY10729 (200 mM) inhibits neutrophil extracellular trap formation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

Human osteosarcoma (U2OS) cells
Concentration:

20 μM
Incubation Time:

72 h
Result:

Showed no reduction in U2OS cell viability relative to DMSO-treated controls.

化学情報

CAS 番号 1644666-57-8
分子量 435.91
分子式 C₁₉H₂₆ClN₇O₃
SMILES

O=C(C1=C(C=CC=C1)C(O)=O)N[C@H](C2=NN(N=N2)C(C)(C)C)CCCNC(CCl)=N
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Subramanian V, et al. Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. J Med Chem. 2015;58(3):1337-1344. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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