1. Epigenetics
  2. Protein Arginine Deiminase
  3. Streptonigrin

Streptonigrin (Synonyms: Bruneomycin)

Cat. No.: HY-124586
Handling Instructions

Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively.

For research use only. We do not sell to patients.

Streptonigrin Chemical Structure

Streptonigrin Chemical Structure

CAS No. : 3930-19-6

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Description

Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively[1].

IC50 & Target

Anti-bacterial[1]
IC50: 48.3±34.2 µM (PAD1), 26.1±0.3 µM, (PAD2), 0.43±0.03 µM (PAD3), 2.5±0.4 µM (PAD4)[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

506.46

Formula

C₂₅H₂₂N₄O₈

CAS No.

3930-19-6

SMILES

O=C(C1=NC(C2=NC3=C(C(C(OC)=C(N)C3=O)=O)C=C2)=C(N)C(C4=CC=C(OC)C(OC)=C4O)=C1C)O

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Streptonigrin
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Streptonigrin

Cat. No.: HY-124586