2. Epigenetics Anti-infection
  3. Protein Arginine Deiminase Antibiotic
  4. Streptonigrin

Streptonigrin  (Synonyms: Bruneomycin)

Cat. No.: HY-124586 Purity: ≥99.0%
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Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively.

For research use only. We do not sell to patients.

Streptonigrin Chemical Structure

Streptonigrin Chemical Structure

CAS No. : 3930-19-6

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Based on 2 publication(s) in Google Scholar

Streptonigrin Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Streptonigrin

WB

    Streptonigrin purchased from MedChemExpress. Usage Cited in: Sci Signal. 2023 Mar 14;16(776):eabq3362.  [Abstract]

    Streptonigrin (SUMOylation agonist; 2, 4, 8 μM; 48 h) markedly increases the amount of IL-33 protein SUMOylation in Huh7 cells transfected with wild-type IL-33.

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    Description

    Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively[1].

    IC50 & Target

    Anti-bacterial[1]
    IC50: 48.3±34.2 µM (PAD1), 26.1±0.3 µM, (PAD2), 0.43±0.03 µM (PAD3), 2.5±0.4 µM (PAD4)[1]
    Molecular Weight

    506.46

    Formula

    C25H22N4O8
    CAS No.
    Appearance

    Solid

    Color

    Light brown to brown

    SMILES

    O=C(C1=NC(C2=NC3=C(C(C(OC)=C(N)C3=O)=O)C=C2)=C(N)C(C4=CC=C(OC)C(OC)=C4O)=C1C)O
    Structure Classification
    Initial Source

    Streptomyces flocculus
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Purity & Documentation

    Purity: ≥99.0%

    COA (250 KB) Elemental Analysis Report (108 KB)

    Handling Instructions (2659 KB)
    References
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    Streptonigrin Related Classifications

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Streptonigrin3930-19-6BruneomycinProtein Arginine DeiminaseAntibioticPeptidylarginine DeiminaseInhibitorinhibitorinhibit

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