Synthesis and cytotoxic activities of 6-chloro-7-arylamino-5,8-isoquinolinediones

  • Bioorg Med Chem Lett. 1999 Apr 19;9(8):1075-80. doi: 10.1016/s0960-894x(99)00152-3.
C K Ryu  1 ,  I K Lee ,  S H Jung ,  C O Lee
Affiliations
  • 1. College of Pharmacy, Ewha Womans University, Seodaemunku, Seoul, Korea.
PMID: 10328288 DOI: 10.1016/s0960-894x(99)00152-3
Abstract

6-Chloro-7-arylamino-5,8-isoquinolinediones were newly synthesized and evaluated for in vitro cytotoxic activities against five human solid tumor cell lines. Among them, 5b, 5c and 5d exhibited potent activities against the cell lines HCT-15 and SK-MEL-2.