Isolation of streptonigrin and its novel derivative from Micromonospora as inducing agents of p53-dependent cell apoptosis

  • J Nat Prod. 2002 May;65(5):721-4. doi: 10.1021/np0104572.
Haishan Wang  1 ,  Su Ling Yeo ,  Jin Xu ,  Xiaoli Xu ,  Hong He ,  Francesca Ronca ,  Anthony E Ting ,  Yue Wang ,  Victor C Yu ,  Mui Mui Sim
Affiliations
  • 1. Medicinal and Combinatorial Chemistry Laboratory, Lead Discovery Group, Microbial Collection, Institute of Molecular and Cell Biology, 30 Medical Drive, Singapore 117609, Singapore.
PMID: 12027749 DOI: 10.1021/np0104572
Abstract

Streptonigrin (1) and its novel natural derivative 7-(1-methyl-2-oxopropyl)streptonigrin (2) were isolated from an actinomycete strain, Micromonospora sp. IM 2670. The inductions for 1 and 2 are more potent in the human neuroblastoma SH-SY5Y cells that contain wild-type p53 than in SH-SY5Y-5.6 cells that overexpress a dominant negative mutant of p53, thus suggesting that they induce Apoptosis through a p53-dependent pathway.