1. Anti-infection
  2. HIV
    Reverse Transcriptase

Islatravir (Synonyms: MK-8591)

Cat. No.: HY-104012
Handling Instructions

Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

For research use only. We do not sell to patients.

Islatravir Chemical Structure

Islatravir Chemical Structure

CAS No. : 865363-93-5

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  • Biological Activity

  • Technical Information

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  • References

Description

Islatravir (MK-8591) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

IC50 & Target[1]

HIV-1 (WT)

0.068 nM (EC50)

HIV-1 (MDR)

0.15 nM (EC50)

HIV-1 (M184V)

3.1 nM (EC50)

In Vitro

Islatravir (MK-8591) (4'Ed2FA) is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively[1].

Clinical Trial
References
Molecular Weight

293.25

Formula

C₁₂H₁₂FN₅O₃

CAS No.

865363-93-5

SMILES

OC[[email protected]]1(C#C)[[email protected]](C[[email protected]](N2C=NC3=C2N=C(F)N=C3N)O1)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Product Name:
Islatravir
Cat. No.:
HY-104012
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Islatravir

Cat. No.: HY-104012