1. Anti-infection
  2. HIV
    Reverse Transcriptase

MK-8591 

Cat. No.: HY-104012
Handling Instructions

MK-8591 is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

For research use only. We do not sell to patients.

MK-8591 Chemical Structure

MK-8591 Chemical Structure

CAS No. : 865363-93-5

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Customer Review

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

MK-8591 is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

IC50 & Target[1]

HIV-1 (WT)

0.068 nM (EC50)

HIV-1 (MDR)

0.15 nM (EC50)

HIV-1 (M184V)

3.1 nM (EC50)

In Vitro

MK-8591 (4'Ed2FA) is a potent anti-HIV-1 agent, acts as a nucleoside reverse transcriptase inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV (WT), HIV (M184V), HIV (MDR), respectively[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4101 mL 17.0503 mL 34.1006 mL
5 mM 0.6820 mL 3.4101 mL 6.8201 mL
10 mM 0.3410 mL 1.7050 mL 3.4101 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

293.25

Formula

C₁₂H₁₂FN₅O₃

CAS No.

865363-93-5

SMILES

OC[[email protected]]1(C#C)[[email protected]](C[[email protected]](N2C=NC3=C2N=C(F)N=C3N)O1)O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
MK-8591
Cat. No.:
HY-104012
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MK-8591

Cat. No.: HY-104012