1. Anti-infection
    Cell Cycle/DNA Damage
  2. Reverse Transcriptase
    DNA/RNA Synthesis
    HIV
  3. EFdA-TP

EFdA-TP 

Cat. No.: HY-138561
Handling Instructions

EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms.

For research use only. We do not sell to patients.

EFdA-TP Chemical Structure

EFdA-TP Chemical Structure

CAS No. : 950913-56-1

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Description

EFdA-TP is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP inhibits HIV-1 RT with multiple mechanisms[1].

IC50 & Target[1]

HIV-1

 

In Vitro

EFdA-TP (0.05-10 μM; for 15 min) inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator. EFdA-TP can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

533.19

Formula

C₁₂H₁₅FN₅O₁₂P₃

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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EFdA-TP
Cat. No.:
HY-138561
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