EFdA-TP tetralithium 

EFdA-TP tetralithium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetralithium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetralithium inhibits HIV-1 RT with multiple mechanisms^[1].

EFdA-TP (0.05-10 μM; for 15 min) tetralithium inhibits RT-catalyzed DNA synthesis as an ICT or DCT^[1].
EFdA-TP tetralithium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator^[1].
EFdA-TP tetralithium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

559.95

C₁₂H₁₄FLi₄N₅O₁₂P₃

Solid

O=[P](O[P](O[P](O)(O)=O)(O)=O)(O[Li])OC[C@]1(O[C@@](C[C@@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C.[Li].[Li].[Li]

Room temperature in continental US; may vary elsewhere.

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

• [1]. Eleftherios Michailidis, et al. 4'-Ethynyl-2-fluoro-2'-deoxyadenosine (EFdA) inhibits HIV-1 reverse transcriptase with multiple mechanisms. J Biol Chem. 2014 Aug 29;289(35):24533-48.  [Content Brief]