1. Anti-infection
    Cell Cycle/DNA Damage
  2. Reverse Transcriptase
    DNA/RNA Synthesis
    HIV
  3. EFdA-TP tetraammonium

EFdA-TP tetraammonium 

Cat. No.: HY-138561A
Handling Instructions

EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits HIV-1 RT with multiple mechanisms.

For research use only. We do not sell to patients.

EFdA-TP tetraammonium Chemical Structure

EFdA-TP tetraammonium Chemical Structure

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1 mg USD 580 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits HIV-1 RT with multiple mechanisms[1].

IC50 & Target[1]

HIV-1

 

In Vitro

EFdA-TP tetraammonium (0.05-10 μM; for 15 min) inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP tetraammonium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator. EFdA-TP tetraammonium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

601.32

Formula

C₁₂H₂₇FN₉O₁₂P₃

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

References
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Product Name:
EFdA-TP tetraammonium
Cat. No.:
HY-138561A
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