1. Anti-infection
    Cell Cycle/DNA Damage
  2. Reverse Transcriptase
    DNA/RNA Synthesis
    HIV
  3. EFdA-TP tetraammonium

EFdA-TP tetraammonium 

Cat. No.: HY-138561A
Handling Instructions

EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits HIV-1 RT with multiple mechanisms.

For research use only. We do not sell to patients.

EFdA-TP tetraammonium Chemical Structure

EFdA-TP tetraammonium Chemical Structure

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Description

EFdA-TP tetraammonium is a potent nucleoside reverse transcriptase (RT) inhibitor. EFdA-TP tetraammonium inhibits RT-catalyzed DNA synthesis as an effective immediate or delayed chain terminator (ICT or DCT). EFdA-TP tetraammonium inhibits HIV-1 RT with multiple mechanisms[1].

IC50 & Target[1]

HIV-1

 

In Vitro

EFdA-TP tetraammonium (0.05-10 μM; for 15 min) inhibits RT-catalyzed DNA synthesis as an ICT or DCT[1].
EFdA-TP tetraammonium can block RT as a translocation-defective RT inhibitor that dramatically slows DNA synthesis, acting as a de facto immediate chain terminator. EFdA-TP tetraammonium can function as a delayed chain terminator, allowing incorporation of an additional dNTP before blocking DNA synthesis[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

601.32

Formula

C₁₂H₂₇FN₉O₁₂P₃

SMILES

O=[P](O[P](O[P](O)(O)=O)(O)=O)(O)OC[[email protected]]1(O[[email protected]@](C[[email protected]@H]1O)([H])N2C3=NC(F)=NC(N)=C3N=C2)C#C.N.N.N.N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

EFdA-TP tetraammoniumReverse TranscriptaseDNA/RNA SynthesisHIVHuman immunodeficiency virusnucleosideRTimmediatedelayedchainterminatorICTDCTdNTPInhibitorinhibitorinhibit

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EFdA-TP tetraammonium
Cat. No.:
HY-138561A
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