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Cat. No.: HY-P1981

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Rpi-856 A

Rpi-856 A is a competitive inhibitor of HIV-1 protease and HTLV-I protease, with an IC₅₀ of 37 nM against HIV-1 protease and an IC₅₀ of 27 nM against HTLV-I protease. Rpi-856 A inhibits Pepsin with an IC₅₀ of 1.9 μM. Rpi-856 A does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 A can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection.

For research use only. We do not sell to patients.

CAS No.: 157381-54-9
Formula: C₄₃H₆₁N₇O₁₃
Molecular Weight:883.98

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

Rpi-856 A Chemical Structure

CAS No.: 157381-54-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

In Vitro

Rpi-856 A (3 h) competitively inhibits recombinant HIV-1 protease (expressed in Escherichia coli MM294 (DE3)/pHIV7004), with a K_i of 13 nM and an IC₅₀ of 37 nM^[1].
Rpi-856 A (3 h) competitively inhibits recombinant HTLV-I protease (expressed in Escherichia coli MM294 (DE3)/pHTI7707) with an IC₅₀ of 27 nM^[1].
Rpi-856 potently inhibits HIV-1 protease in cell-free biochemical assays, with an IC₅₀ value of 37 nM^[2].
Rpi-856 A inhibits porcine pepsin with an IC₅₀ of 1.9 μM, and its activity is weaker than that against retroviral protease^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 157381-54-9
Molecular Weight 883.98
Formula C₄₃H₆₁N₇O₁₃
Sequence

Val-{Gly(2-(3,5-dihydroxyphenyl))}-Leu-{2-oxo-4-phenyl-3-aminobutanoyl}-Val-Val-Asp
Sequence Shortening

V-{Gly(2-(3,5-dihydroxyphenyl))}-L-{2-oxo-4-phenyl-3-aminobutanoic acid}-VVD
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Asano T, et al. Novel retrovirus protease inhibitors, RPI-856 A, B, C and D, produced by Streptomyces sp. AL-322. J Antibiot (Tokyo). 1994 May;47(5):557-65.

[2]. Kitazaki T, et al. Synthesis and human immunodeficiency virus (HIV)-1 protease inhibitory activity of tripeptide analogues containing a dioxoethylene moiety. Chemical & pharmaceutical bulletin. 1994 Dec;42(12):2636-40.

[3]. Huh, et al. Anti-Obesitic Effects of Cathepsin S Inhibitory Fraction Derived from Paecilomyces Tenuipes in Mice Fed a High-Fat Diet. 2009.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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