157381-54-9
Chemical Structure
Rpi-856 A
- CAS No.: 157381-54-9
- Formula:C43H61N7O13
- Molecular Weight:883.98
IUPAC Name: (3-(2-(2-(2-amino-3-methylbutanamido)-2-(3,5-dihydroxyphenyl)acetamido)-4-methylpentanamido)-2-oxo-4-phenylbutanoyl)valylvalylaspartic acid
InChIKey: FXQIFOQIICEJDA-TWXSNOTASA-N
SMILES: O=C(C[C@@H](C(O)=O)NC([C@H](C(C)C)NC([C@H](C(C)C)NC(C(C(CC1=CC=CC=C1)NC([C@H](CC(C)C)NC(C(C2=CC(O)=CC(O)=C2)NC([C@H](C(C)C)N)=O)=O)=O)=O)=O)=O)=O)O
Biological Activity: Rpi-856 A is a competitive inhibitor of HIV-1 protease and HTLV-I protease, with an IC50 of 37 nM against HIV-1 protease and an IC50 of 27 nM against HTLV-I protease. Rpi-856 A inhibits Pepsin with an IC50 of 1.9 μM. Rpi-856 A does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 A can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection[1][2].
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Rpi-856 A | Rpi-856 A is a competitive inhibitor of HIV-1 protease and HTLV-I protease, with an IC50 of 37 nM against HIV-1 protease and an IC50 of 27 nM against HTLV-I protease. Rpi-856 A inhibits Pepsin with an IC50 of 1.9 μM. Rpi-856 A does not inhibit chymosin, trypsin, chymotrypsin, papain, bromelain, thermolysin, prolyl endopeptidase, carboxypeptidase A or carboxypeptidase B. Rpi-856 A can be used in the research of acquired immunodeficiency syndrome (AIDS) and related diseases, as well as HIV infection. | |||||||||||||||||||||
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References
- [1]. Asano T, et al. Novel retrovirus protease inhibitors, RPI-856 A, B, C and D, produced by Streptomyces sp. AL-322. J Antibiot (Tokyo). 1994 May;47(5):557-65.
- [2]. Kitazaki T, et al. Synthesis and human immunodeficiency virus (HIV)-1 protease inhibitory activity of tripeptide analogues containing a dioxoethylene moiety. Chemical & pharmaceutical bulletin. 1994 Dec;42(12):2636-40.
