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製品番号: HY-187572

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KNI-10033

KNI-10033 is a HIV-1 protease inhibitor with a K_d value of 13 pM for both wild-type and pseudo-wild-type human HIV-1 protease. KNI-10033 can be used in studies related to HIV infection and acquired immunodeficiency syndrome (AIDS).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 944476-53-3
分子式: C₄₀H₄₅N₅O₇S₂
分子量:771.94

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

KNI-10033 構造式

CAS 番号: 944476-53-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

KNI-10033 binds potently to wild-type HIV-1 protease with a K_d value of 13 pM^[1].
KNI-10033 (46-57 μM) binds tightly to pseudo-wild-type HIV-1 protease, with a K_d value of 13 pM at 25 °C^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 944476-53-3
分子量 771.94
分子式 C₄₀H₄₅N₅O₇S₂
SMILES

O=C([C@H]1N(CSC1(C)C)C([C@@H](O)[C@@H](NC([C@H](CSC)NC(COC2=CC=CC3=C2C=CN=C3)=O)=O)CC4=CC=CC=C4)=O)N[C@H]5C6=CC=CC=C6C[C@H]5O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Freire E, et al. Do enthalpy and entropy distinguish first in class from best in class?. Drug discovery today. 2008 Oct;13(19-20):869-74.

[2]. Edwards AA, et al. Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase. Biochemistry. 2009 Jun 16;48(23):5226-38.

[3]. Kar P, et al. Importance of polar solvation and configurational entropy for design of antiretroviral drugs targeting HIV-1 protease. The journal of physical chemistry. B. 2013 May 16;117(19):5793-805.

[4]. Lafont V, et al. Compensating enthalpic and entropic changes hinder binding affinity optimization. Chemical biology & drug design. 2007 Jun;69(6):413-22.

[5]. Scott DJ, et al. Extreme enthalpy‒entropy compensation in the dimerization of small solutes in aqueous solution. European biophysics journal : EBJ. 2024 Nov;53(7-8):373-384.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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