Atevirdine mesylate
Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 138540-32-6
- Formel: C22H29N5O5S
- Molecular Weight:475.56
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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Help & FAQs
Biologische Aktivität
Beschreibung
IC50 & Target
[1]|
HIV-1 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MT2 | CC50 |
>20 μM
Compound: 80
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Tested for the drug concentration required to decrease HIV-1IIIb infected MT-2 cell viability compared to uninfected controls
Tested for the drug concentration required to decrease HIV-1IIIb infected MT-2 cell viability compared to uninfected controls
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[PMID: 7512142] |
| MT2 | ED50 |
<0.2 μM
Compound: 80
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Effective antiviral dose required to block the spread of HIV-1 IIIb infection in MT-2 cells by monitoring the formation of syncytia
Effective antiviral dose required to block the spread of HIV-1 IIIb infection in MT-2 cells by monitoring the formation of syncytia
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[PMID: 7512142] |
Chemical Information
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CAS. Nr. 138540-32-6
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Molecular Weight 475.56
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Formel C22H29N5O5S
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SMILES
CS(=O)(O)=O.CCNC1=C(N2CCN(C(C3=CC4=C(C=CC(OC)=C4)N3)=O)CC2)N=CC=C1
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Synonyms
U 87201E mesylate
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Atevirdine mesylate Related Classifications
HY-105097 Related Classifications
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