2. Anti-infection
  3. HIV Reverse Transcriptase
  4. Atevirdine mesylate

Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS.

For research use only. We do not sell to patients.

Atevirdine mesylate

Atevirdine mesylate Chemical Structure

CAS No. : 138540-32-6

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Atevirdine mesylate Related Antibodies

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Description

Atevirdine (U 87201E) mesylate is a nonnucleoside reverse transcriptase (NNRT) inhibitor. Atevirdine mesylate can inhibit human immunodeficiency virus type 1 (HIV-1) with an IC50 of 0.06-1.6 μM. Atevirdine mesylate shows highly synergistic effects against Zidovudine/Didanosine-resistant clinical isolates of HIV-1 companied with Zidovudine (HY-17413)/Didanosine (Hy-B0249). Atevirdine mesylate can be used for the research of AIDS[1].

IC50 & Target[1]

HIV-1

 

Cellular Effect
Cell Line Type Value Description References
MT2 CC50
> 20 μM
Compound: 80
Tested for the drug concentration required to decrease HIV-1IIIb infected MT-2 cell viability compared to uninfected controls
Tested for the drug concentration required to decrease HIV-1IIIb infected MT-2 cell viability compared to uninfected controls
[PMID: 7512142]
MT2 ED50
< 0.2 μM
Compound: 80
Effective antiviral dose required to block the spread of HIV-1 IIIb infection in MT-2 cells by monitoring the formation of syncytia
Effective antiviral dose required to block the spread of HIV-1 IIIb infection in MT-2 cells by monitoring the formation of syncytia
[PMID: 7512142]
Molecular Weight

475.56

Formula

C22H29N5O5S
CAS No.
SMILES

CS(=O)(O)=O.CCNC1=C(N2CCN(C(C3=CC4=C(C=CC(OC)=C4)N3)=O)CC2)N=CC=C1
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Atevirdine mesylate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Atevirdine138540-32-6U 87201EHIVReverse TranscriptaseHuman immunodeficiency virusInhibitorinhibitorinhibit

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